Plant encounters biotic stress from diverse organisms such as bacteria, fungi, viruses and nematodes. Common diseases such as mildew, wilt, root rot, blast, decay, rust can significantly damage the important crop species of different families mainly Cucurbitaceae, Fabaceae, Poaceae and Solanaceae. Application of number of bactericides, fungicides etc., of various types has been considered as the only method to manage pathogens and enhance crop production and productivity. As a result, overuse of chemicals raised concerns about residual effects, disease resistance to active ingredients, including health and the environment. In this regard, the potential application of seed priming methods provides an alternate technique for effectively managing diverse diseases from sowing till harvesting. Seed priming methods namely hydro-priming, osmo-priming, chemical priming, bio-priming and nano-priming induces the disease resistance through signalling molecules, enzyme activation, molecular mechanism and epigenetic reprogramming. Incidence of Fusarium culmorum and Aspergillus niger in wheat, Sclerotium rolfsii in chickpea, Sclerospora graminicola in pearl millet and yellow mosaic virus of mung bean are found to decreased with the adoption of hydropriming. Chemical priming reported to reduce the incidence of downy mildew in sunflower and pear millet, Whereas seed priming with beneficial microbes and nano materials induced resistance against various diseases in rice tomato and cucumber. As a result, the review establishes impact of various seed priming methods and its mechanism against diverse biotic stresses. Through this, seed priming technology provides number of benefits and contributes for sustainable way of diseases management.