This issue explores the evolving field of Virtual Reality (VR) as a transformative tool in psychotherapy through the presentation of five clinical case studies and a framework for their analysis. As technological advancements increase accessibility to VR and a growing body of scientific evidence supports VR-based psychological interventions the potential for innovative VR applications in psychotherapy continues to expand. We propose a framework for conceptualizing VR psychotherapeutic interventions along three key dimensions: Strategy, Focus, and Perspective. The goal of this conceptual framework is to provide guidance for clinicians and researchers in designing effective interventions and broadening the scope of therapeutic possibilities. The five clinical cases featured in this issue span a wide range of psychological conditions, including chronic pain, PTSD, social anxiety, depression, and psychosis. The VR interventions draw from diverse theoretical approaches, including cognitive-behavioral therapy, acceptance and commitment therapy, systemic therapy, and personal construct therapy. Each contribution demonstrates how VR can enhance therapy, offering clients immersive and emotionally intense experiences that might foster personal growth, symptom reduction, and therapeutic breakthroughs. By presenting both well-established and innovative uses of VR, this issue provides valuable insights into how virtual environments can extend the boundaries of psychotherapy, addressing complex psychological issues in novel, impactful, and unique ways.