Aqueous zinc ion batteries (ZIBs) are currently highly promising rechargeable batteries offering affordable prices and high reliability. However, the uncontrolled expansion of zinc dendrites, hydrogen evolution reaction, and adverse reaction greatly affect their potential sustainable application. In this work, we constructed Cu-Sn nanoparticle alloy modified carbon nanofibers (Cu/Sn-C) as a buffer interface region (BIR) onto the zinc anode. The high density of zincophilic sites of the Cu/Sn-C contributed a homogeneous Zn deposition behavior, ameliorated potential separator penetration of zinc dendrites, and weakened corrosions and adverse reactions. As a result, Cu/Sn-C exhibits a low zinc nucleation overpotential of 33.2 mV and dendrite-free zinc deposition. Besides, a symmetric cell with Cu/Sn-C@Zn anode exhibits outstanding cycling lifespan with over 3500 hours at 1 mA cm -2 for 1 mAh cm -2. Furthermore, Cu/Sn-C@Zn//Mn xV 2O 5 full battery also achieved stable cycling at 5 A g -1. This work provides a significant avenue for enhancing the reliability of the Zn anode, thereby facilitating the advancement of widespread applications for the next-generation AZIBs.