Background: Polycystic ovarian disease is the most prevalent endocrine ailment that affects a woman’s hormones, menstrual cycle, fertility, and physical appearance among women age group of 14-35 years. Teenagers who have poor eating habits and little exercise are more likely to develop disorders like polycystic ovarian disease (PCOD). Objectives: The aim of this study to assess the knowledge regarding PCOD and to evaluate the effectiveness of planned teaching programme regarding PCOD among high school girls. Materials and Methods: Quantitative evaluative research approach was used in this study. The research design was Pre-experimental one -group pre-test, post-test research design. The study was conducted at CKS High school Hassan, Karnataka. A total 100 high school students were willing to participate in the study. Main outcome measures to see the effective to improve the knowledge among high school girls. Results: Among 100 students (69%) of the respondents had adequate knowledge, 31% of them had moderate knowledge regarding poly-cystic ovarian disease. The mean knowledge score 19.07± 4.0 and 32.80±2.73. The Calculated paired‘t’ test value was 42.35 (p<0.05, df= 99), Conclusion: The researcher concluded that the planned teaching programme was more effective. The findings of the study suggest that the adolescent girl were having less on PCOD, So Obstetrics and Gynecological nurses, nurse educators and researchers play a vital role in both prevention of infertility and development of better management technique to encounter the problems in adolescent girls with PCOD.