not-yet-known not-yet-known not-yet-known unknown Prostate cancer is the most frequently diagnosed cancer and the deadliest malignancy of the male urinary system. Patients’ clinical progression and outcomes vary widely; however, in recent years, major advancements in both diagnosis and treatment have occurred, particularly with the application of nanotechnology in this field. Despite the substantial number of original articles and reviews published annually on prostate cancer diagnosis and treatment, no bibliometric analysis has been conducted on this topic. This study aimed to identify key themes, research hotspots, and knowledge gaps regarding the use of nanotechnology in prostate cancer diagnosis and treatment through bibliometric analysis and visualization of the literature. It also involved summarizing recent advancements to explore new research directions. We analyzed the quantity and quality of publications on nanotechnology for prostate cancer diagnosis and treatment using the Web of Science core collection database. We then examined publishing trends by country, institution, and author, and assessed cooperation networks. Subsequently, we categorized and summarized research “hot topics,” and summarized the latest findings regarding nanotechnology for prostate cancer diagnosis and treatment.