Acute Generalized Exanthematous Pustulosis (AGEP): Our Pediatric Cases And MimickersTo the EditorAcute generalized exanthematous pustulosis (AGEP) is a rare, severe skin reaction with an annual incidence of approximately 1 to 5 cases (1). The main etiologic factor is drugs, but other triggers such as infections (Chlamydia pneumoniae, Mycoplasma pneumoniae, Coccidiomycosis, COVID-19, Cytomegalovirus, Epstein-Barr virus and Parvovirus B19) and vaccines have also been reported to play a role in the development of the disease (2). The drugs most frequently associated with AGEP are mainly beta-lactam group antibiotics (ampicillin/amoxicillin), quinolones, antimalarials (hydroxychloroquine), sulfonamides, macrolides, calcium channel blockers and antimycotic drugs (terbinafine) (3). Skin involvement is characterized by the sudden appearance of sterile, pinpoint-sized pustules, usually on an edematous and erythematous background. Although mucosal involvement is rare, it usually has a mild course and is limited to a single site; the oral mucosa is most commonly affected. Systemic findings including fever and leukocytosis usually accompany skin findings (4).The diagnosis is based on clinical and histopathologic findings. The AGEP validation score was developed by the European Study of Severe Cutaneous Adverse Reactions (EuroSCAR) group (5).Here, we present five cases of AGEP and five cases of Generalized Pustular Psoriasis (GPP) and Herpes dermatitis with vesiculopustular rashes. The presented cases emphasize that dermatologic and infectious diseases with similar clinical findings should be considered in the differential diagnosis of AGEP.