Objectives Analyze the trends and inequalities in type 2 diabetes mellitus (T2DM) prevalence among women of childbearing age (WCBA) from 1992 to 2021. Design: Population-based analysis. Setting: T2DM prevalence data were obtained from GBD2021. Population: Participants in GBD2021. Methods T2DM prevalence data from GBD 2021 database were analyzed using Age-Period-Cohort (APC). Inequalities across SDI levels were also assessed, and decomposition analysis identified burden drivers. Bayesian APC (BAPC) model provided future projections (2022-2030). Main outcome measures Prevalence number (million), age-standardized rate (ASR, per million), net drift (%). Results In 2021, the global T2DM prevalence among WCBA reached 73.86 (95% UI: 63.43-85.32) million. From 1992 to 2021, the prevalence burden rose in 195 countries, declined in eight, and remained stable in one. Greenland exhibited the largest rise with a net drift of 11.32% (95% UI: 8.33-14.39%). The highest burden worsened over time and ASR peak occurred in the 45-49 age group. Population and epidemiological factors was the main driver relatively in low and high SDI regions. T2DM-related visual impairment was more severe in low and medium SDI regions. Projections suggest significant increases both on global and country level. Conclusions T2DM prevalence among WCBA has risen steadily since 1992, with worsening inequalities. Projections to 2030 underscore the urgent need for targeted prevention and treatment strategies.
