Chronic stress typically provokes immunosuppression, activates tyrosine kinase (TK), and promote inflammatory responses. According to Persian medicine, the spleen plays an important role in immune system and stress response. The properties of Cuscuta epithymum (CE) are considered high through its effects on the immune system and its antioxidant effects. In this experimental study, 50 male and 15 female rats were randomly assigned into four groups and were subjected to restraint stress once a day continuously. At the same time, control and stress rats received normal saline and the other two groups received Cuscuta’s extract. Control and experimental rats were mated to create four types of coupling combinations as follows McFc, MsFs, McFc+EX, MsFs+EX (M: male, F: female, C: control, S: stress, EX: extract). Then, some parents and male pups were dissected on postnatal day (PND) 25; TK level, megakaryocyte, and macrophage cell number in the liver and spleen were evaluated. Quantitative expression of TNF-α and IL-1β protein in the brain were examined by western blot. The level of TK and macrophage cells in the liver and spleen tissues significantly increased in stressed rats compared to the others, while they were significantly decreased in the stress+CE group. Megakaryocyte cells significantly decreased in the stress group while they leveled up in the CE treated rats. Cuscuta extract significantly reduced the TNF-α and IL-1β levels in the brain homogenate. Cuscuta is effective in reducing the adverse effects of stress on the liver and spleen immune system. Also, it shows anti- neuroinflammatory effects.