Alzheimer’s disease (AD) manifests by many behavioral changes, including anxiety and social withdrawal, which often precede and accompany cognitive decline. The TgF344-AD rat model recapitulates several AD-like pathological features and cognitive deficits, yet the progression of anxiety-like and social behavior impairments remains poorly characterized. In this study, we investigated anxiety-like and social behaviors in male and female TgF344-AD rats at 10 and 14 months of age using the open-field task, elevated plus-maze, and social interaction paradigms. While standard anxiety measures showed limited genotype effects, we observed subtle behavioral alterations in 10-month-old TgF344-AD rats, including decreased exploratory behavior and reduced locomotor activity in the elevated plus-maze. Notable social interaction deficits were identified in TgF344-AD rats, persisting across both age points. Our behavioral assessment provides an essential characterization of this model at intermediate disease stages when neuropathological changes and cognitive symptoms typically emerge. Most importantly, this work provides evidence for social behavior deficits in the TgF344-AD model and contributes to the understanding of non-cognitive changes in AD.