|
Early Onset FGR
< 32w
EFW < 3%
N=36
|
Late Onset FGR
> 32w
EFW < 3%
N=10
|
Early Onset SGA < 32w
EFW 4-10%
N=21
|
Late Onset SGA > 32w
EFW 4-10%
N=12
|
FGR/SGA
N= 79
|
EFW 11-90%
N=213
|
|
|
Placental Growth Factor (PlGF) |
|
|
|
|
|
|
|
|
Low (≤5%)
|
27
75%
|
7
70%
|
12
57%
|
4
33%
|
50
63%
|
55
26%
|
4.9
(2.9-8.5)
|
<0.0001*
|
Normal (≥10%)
|
9
25%
|
3
30%
|
9
43%
|
8
67%
|
29
37%
|
158
74%
|
|
|
US Findings |
|
|
|
|
|
|
|
|
Abnormal Placental Morphology
|
22
61%
|
6
60%
|
14
67%
|
7
58%
|
49
62%
|
50
23%
|
5.3
(3.1-9.1)
|
<0.0001*
|
Perinatal Outcomes |
|
|
|
|
|
|
|
|
Preeclampsia at any Gestational Age
|
14
39%
|
4
40%
|
4
19%
|
5
42%
|
27
34%
|
56
26%
|
1.5
(0.84-2.52)
|
0.18*
|
Fetal Demise (IUFD)
|
4
11%
|
0
0%
|
1
5%
|
1
8%
|
6
7.6%
|
1
0.5%
|
12.5
(2.08-75.42)
|
0.001**
|
Preterm birth < 34 weeks
|
20
56%
|
3
30%
|
5
23%
|
1
8%
|
29
37%
|
27
13%
|
3.99
(2.12-7.22)
|
<0.0001*
|
Birthweight < 3%
|
10
28%
|
2
20%
|
0
0%
|
1
8%
|
13
16.5%
|
4
2%
|
10.3
(3.28-29.46)
|
<0.0001**
|
Admission to NICU
|
18
50%
|
8
80%
|
8
38%
|
3
25%
|
37
47%
|
40
19%
|
3.81
(2.15-6.52)
|
<0.0001*
|
Placental Pathology |
|
|
|
|
|
|
|
|
Confirmed Maternal/Fetal Vascular Malperfusion (MVM/FVM)
|
21
58%
|
5
50%
|
10
48%
|
4
33%
|
40
51%
|
27
13%
|
7.06
(3.92-12.62)
|
<0.0001*
|