Conclusion

This paper designed a high frequency AC generator (200 kHz) power by 3.7 V DC lithium battery for application of tumor treating field. The following conclusions can be derived: 1) The LCLC step-up resonant with 1:1 linear transformer (LCLLC) was proposed to boost the voltage. Based on the theoretical analysis, with proper selection of excitation inductances of linear transformer, the LCLLC step-up resonant could shift resonant gain frequency to the targeted frequency (200 kHz), then achieve a high voltage gain. With a large range of excitation inductances, the resonant frequency changes in a relatively narrow change, which indicates that it is a proper way to select adaptive excitation inductance of transformer for fine tuning of targeted frequency to resonant frequency. 2) A prototype powered by 3.7 V DC lithium battery is designed to output high frequency AC field (200 kHz). The designed generator could output 66 V AC field (200 kHz) with a voltage gain of 17.8 (3.7 V DC supply). For bio-load impedances of 60, 75, and 90 Ω, the excitation inductances of linear transformer were properly selected to achieve same output voltage (50 V). The prototype could sustainably run for about 8 hours when powered by four 3.7 V lithium batteries (5.1 W). 3) The finite element model was used to simulate electric field distribution with designed insulated electrodes. The results showed that high dielectric constant of ceramic section of electrode could contribute to deliver electric field to targeted region. The in vitro cell experimental indicates that the designed prototype could output proper AC field with 200 kHz by designed insulated electrodes to inhibit cell proliferation significantly.Acknowledgements This work was supported in part by the National Natural Science Foundation of China under Grant 52007172, in part by the China Postdoctoral Science Foundation under Grant 2020M672273, in part by Henan Province Scientific Research Joint Fund Industrial Category Major Program under Grant 245101610001, in part by Natural Science Foundation of Henan Province under Grant 222300420538.Author Contributions Yanpeng Lv: Conceptualization, Investigation, Supervision, Methodology, Project administration. Shihan Lu Software, Writing-original draft. Yuqi Wang: Analyzed data, Debugging prototypeXuan Liu: Design experiments. Jianhua Zhang: Data curation, Visualization, Writing-review & editing.