Conclusion
This paper designed a high frequency AC generator (200 kHz) power by 3.7
V DC lithium battery for application of tumor treating field. The
following conclusions can be derived:
1) The LCLC step-up resonant with 1:1 linear transformer (LCLLC) was
proposed to boost the voltage. Based on the theoretical analysis, with
proper selection of excitation inductances of linear transformer, the
LCLLC step-up resonant could shift resonant gain frequency to the
targeted frequency (200 kHz), then achieve a high voltage gain. With a
large range of excitation inductances, the resonant frequency changes in
a relatively narrow change, which indicates that it is a proper way to
select adaptive excitation inductance of transformer for fine tuning of
targeted frequency to resonant frequency.
2) A prototype powered by 3.7 V DC lithium battery is designed to output
high frequency AC field (200 kHz). The designed generator could output
66 V AC field (200 kHz) with a voltage gain of 17.8 (3.7 V DC supply).
For bio-load impedances of 60, 75, and 90 Ω, the excitation inductances
of linear transformer were properly selected to achieve same output
voltage (50 V). The prototype could sustainably run for about 8 hours
when powered by four 3.7 V lithium batteries (5.1 W).
3) The finite element model was used to simulate electric field
distribution with designed insulated electrodes. The results showed that
high dielectric constant of ceramic section of electrode could
contribute to deliver electric field to targeted region. The in
vitro cell experimental indicates that the designed prototype could
output proper AC field with 200 kHz by designed insulated electrodes to
inhibit cell proliferation significantly.Acknowledgements This work was supported in part by the
National Natural Science Foundation of China under Grant 52007172, in
part by the China Postdoctoral Science Foundation under Grant
2020M672273, in part by Henan Province Scientific Research Joint Fund
Industrial Category Major Program under Grant 245101610001, in part by
Natural Science Foundation of Henan Province under Grant 222300420538.Author Contributions Yanpeng Lv: Conceptualization,
Investigation, Supervision, Methodology, Project administration. Shihan
Lu Software, Writing-original draft. Yuqi Wang: Analyzed data,
Debugging prototypeXuan Liu: Design experiments. Jianhua Zhang: Data
curation, Visualization, Writing-review & editing.