Background: Total pelvic exenteration (TPE) is a radical procedure for pelvic cancer recurrence. Wet colostomy simplifies reconstruction, reducing operative time and complications. Objective: To demonstrate the feasibility of a single-port robotic-assisted (SP) TPE with wet colostomy. Methods: A voice-commented video article from the National Cancer Institute “Fondazione Pascale” details a Da Vinci SP®-assisted procedure. Results: A 68-year-old woman underwent TPE in 320 minutes with 50 cc blood loss, no transfusions, and was discharged on day 4 without complications. Conclusion: This is the first SP robotic-assisted TPE with wet colostomy, demonstrating its feasibility and surgical strategy.