Lysophosphatidic Acid Receptors (LPAR)
Lysophosphatidic acid (LPA), a bioactive lipid, is involved in various physiological processes, including cancer and immune response (Geraldoet al. , 2021). LPA is frequently elevated in the tumor microenvironment, affecting immune cell migration, survival, and cytokine production, shaping the immune landscape within tumors. LPA-LPAR interactions also influence the recruitment of immune cells, impacting both innate and adaptive immune responses (S. C. Lee et al. , 2020).