Lysophosphatidic Acid Receptors (LPAR)
Lysophosphatidic acid (LPA), a bioactive lipid, is involved in various
physiological processes, including cancer and immune response (Geraldoet al. , 2021). LPA is frequently elevated in the tumor
microenvironment, affecting immune cell migration, survival, and
cytokine production, shaping the immune landscape within tumors.
LPA-LPAR interactions also influence the recruitment of immune cells,
impacting both innate and adaptive immune responses (S. C. Lee et
al. , 2020).