Thyroid-stimulating hormone
receptor (TSHR)
|
Class A
|
N-terminal, ICL3, TM6, ECL2, ECL3
|
↑cAMP
|
(Bonomi et al., 2001; Miyai, 2007)
|
Melanocortin 1 receptor
(MC1R)
|
Class A
|
TM2, ICL2
|
activation of MAPK/ERK, mTor
|
(JA & Bishop, 2005; Turan et al., 2012)
|
Melanocortin 2 receptor
(MC2R)
|
Class A
|
S74I,R137W, Y254C
|
defective trafficking to cell surface
|
(Flück et al., 2002)
|
Lutropin receptor
(LHR)
|
Class A
|
TM3, TM6
|
↑cAMP
|
(G. Liu et al., 1999)
|
Smoothened receptor
(SMO)
|
Class F
|
N-terminal, TM6, TM7
|
CA of Hedgehog pathway
|
(Reifenberger et al., 1998; Wang et al., 2014)
|
Follicle-stimulating hormone receptor (FSHR) |
Class A |
ECL2, TM4, TM6 |
↑cAMP |
(Tao, 2008) |
Glutamate family of G protein-linked receptors (GRM1–8) |
Class A |
N-terminal, ECL1, ECL2, C-terminal |
activation of the Hedgehog pathway |
(Elia et al., 2012; Kan et al., 2010) |
Muscarinic acetylcholine receptor (mAChR) |
Class A |
N-terminal, TM2,
TM3, ICL3 |
activating and inactivating mutations |
(Kruse et
al., 2012) |
Lysophosphatidic acid receptor (LPAR) |
Class A |
ICL2, ICL4, TM4, TM6,
TM7 |
activating mutations |
(Raza et al., 2014) |
Sphingosine 1-phosphate receptor (S1PR) |
Class A |
N-terminal, TM4 |
inactivating mutations |
(Obinata et al., 2014) |
Abbreviations: ICL- Intracellular loop, ECL- Extracellular loop, TM-
Transmembrane α-helix, CA- constitutive activity |
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