AUTHOR CONTRIBUTIONS
CHL and CHT conducted the clinical study, performed the experiments,
analyzed the data, and wrote the manuscript. CHL designed and performed
in vitro and in vivo mice experiments and analyzed the data. IOP helped
the in vitro experiments of the Treg suppression assay. PCC helped the
in vivo animal experiments. TFT and HJW conducted the clinical trial and
collected clinical samples. SYC provided advice about experiments of
CyTOF and scRNA analysis. HYC and SHC helped with sample preparation for
CyTOF. FTL and PHL provided advice about the interpretation of the data
and revised the manuscript. YLL conceived and initiated the project,
designed the study, raised the grant funding, and revised the
manuscript. All authors edited, approved, and provided critical comments
on the manuscript.