AUTHOR CONTRIBUTIONS
CHL and CHT conducted the clinical study, performed the experiments, analyzed the data, and wrote the manuscript. CHL designed and performed in vitro and in vivo mice experiments and analyzed the data. IOP helped the in vitro experiments of the Treg suppression assay. PCC helped the in vivo animal experiments. TFT and HJW conducted the clinical trial and collected clinical samples. SYC provided advice about experiments of CyTOF and scRNA analysis. HYC and SHC helped with sample preparation for CyTOF. FTL and PHL provided advice about the interpretation of the data and revised the manuscript. YLL conceived and initiated the project, designed the study, raised the grant funding, and revised the manuscript. All authors edited, approved, and provided critical comments on the manuscript.