Background: The association of cancer and pregnancy is rare, with an incidence of approximately 1:1000 pregnancies. Objective: To determine the familial impact of cancer diagnosis in pregnant women Material and Methods: An observational, cross-sectional, descriptive study was conducted on women with cancer during pregnancy at the Regional General Hospital No. 17 in Cancun, Mexico, from 2017 to 2020. After informed consent, an interview was conducted with women with a recent diagnosis of cancer and pregnancy, family functionality, quality of life, and family impact were recorded, a clinical variable about gestation and control prenatal. The family impact was considered as the variable composed of functionality and quality of life determined by the EORTC QLQ-C30 instrument. Results: 67 pregnant women diagnosed with cancer were included. With cervical cancer 36% [95%CI:24.34,47.30]. Breast cancer. 18% [95%CI:8.72, 27.09] Age μ31.4±4.9 years. 69% [95%CI: 57-80] received surgical treatment. Systemic treatment. 31%[95%CI:19-42]. Vaginal delivery was 31% [95%CI:12-31], and cesarean section 69% [95%CI:57-80]. Prenatal control 51% [95% CI 39-62] four or more consultations. Comorbidity 48% [95% CI: 47.49, 77.50]. Quality of life is 100% affected. 85% bad 95% CI [75.73-94.27]. Severe dysfunction was observed in 85% [95%CI: 75.73-73.94] of families and the impact of cancer was negative in 100%. Conclusions: Although the diagnosis of cancer during pregnancy is a rare event, it was found that it hurts the family, which translates into family crises during the disease process, which are expressed as family dysfunction and poor quality of life.