This paper examines the causality and transmission mechanism between Taiwan’s GPR and global supply chain pressure (GSCP). The employment of the bootstrap rolling-window Granger causality test facilitates the identification of the time-varying transmission mechanism. The positive one suggests that GPR leads to supply chain disruptions and increases transport costs, thus increasing the economic uncertainty of Taiwan, and the negative one indicates that GPR promotes restructuring and innovation of industries, hence improving supply chain resilience. In turn, GPR is positively influenced by GSCP, which suggests that the restructuring of supply chains leads to pressure on Taiwan to shift the industrial chain and thus at risk of marginalisation. The results suggest Taiwan’s high dependence on the GSCP makes it vulnerable to external GPR shocks. The findings are consistent with the dependency theory that Taiwan, as a resource controller, has an economy which is highly dependent on GSCP.