Alzheimer‘s disease, the most common type of dementia, is a serious neurodegenerative disorder for which there is currently no cure. The research was carried out in order to determine the significance of Mir 30c, and Mir 155 in serving as a diagnostic biomarker .The microarray data set GSE138260 was obtained from the GEO database hosted by the NCBI. Blood samples were collected from 30 individuals with Alzheimer‘s disease and 30 individuals without the condition. RNA was extracted from the serum samples, converted to cDNA, and then the real-time PCR method was used to measure the expression level of Mir 30c and Mir 155 . The study‘s finding indicated that the copy number levels of Mir 30c and Mir 155 were increased. Bioinformatics analysis revealed that these microRNA target pathways are associated with Alzheimer‘s disease. The cut-off value for this Mir´s demonstrates the trade-off between sensitivity and specificity in diagnostic testing.