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\begin{document}
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\title{Title of Original Paper}



\vspace{-1em}



  \date{}


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First Name(s) Surname\(^1\), First Name(s)
Surname\(^1\), First Name(s) Surname\(^2\)*,
First Name(s) Surname\(^3\), First Name(s)
Surname\(^1\)

\(^1\) Institute Name, Department, University / Hospital,
City, (State,) Country

\(^2\) Institute Name, Department, University / Hospital,
City, (State,) Country

\(^3\) Institute Name, Department, University / Hospital,
City, (State,) Country

\par\null

Short Title: to be used as running head

\par\null

*Corresponding Author

Full name:

Institute:

Department:

University / Hospital:

Street Name \& Number:

City, State, Postal code, Country:

Tel:

Fax:

E-mail:

\par\null

Key Words: Please provide 3-5 keywords related to your manuscript

\emph{What is it About?:}~A summary of no more than 100 words to explain
the article in simple terms and to increase visibility in other
disciplines / for a general readership.

\par\null

\pagebreak

\section{Abstract}

{\label{866680}}

The abstract should summarize the main points and reflect the content of
an article. It should be written in a clear and simple way and
unstructured set in one paragraph. Abbreviations used in the main text
may be introduced and used. Do not use bibliographic references nor
references to figures or tables.

For the accepted length (word count) or journal-specific variations,
consult the specific Author Guidelines.

\section{Introduction}

{\label{556285}}

The Introduction should provide a summary of the background to the
relevant field of research and the specific problems addressed and
should state the hypotheses being explored as well as the main goal(s)
of the study. Conclusions or findings should not appear in the
Introduction.

\section{Materials and Methods}

{\label{211588}}

The Materials and Methods should clearly list all inclusion and
exclusion criteria, methods of research as well as variables evaluated
and should state how outcomes were assessed. All terms should be
adequately defined and statistical information should be in enough
detail so that a study can be repeated.

\section{Results}

{\label{302232}}

The Results section should describe the most important findings of the
study, analysis, or experiment. The most important results should be
indicated and relevant trends and patterns should be described.

\section{Discussion / Conclusion}

{\label{380491}}

The Discussion should provide an evaluation of the results. There should
be a clear discussion of the implications, significance, and novelty of
the results presented and of whether the data support or contradict
previous studies.

\section{Appendix}

{\label{708824}}

Appendices may contain complementary information that was not integrated
into the main text (tables, figures, formulas). They may include
references, which should be listed in the general reference list of the
manuscript, however, tables and figures should be numbered separately.

\section{Supplementary Material}

{\label{603339}}

Supplementary materials, which are directly relevant but not essential
to the conclusions of the paper, may be submitted as separate files.
Further Information on supplementary material can be found in the
Guidelines for Authors.

\section{Statements}

{\label{928181}}

All papers must contain the following statements after the main body of
the text and before the reference list:

\subsection{Acknowledgement}

{\label{930046}}

In the Acknowledgement section, authors must include individuals and
organizations, who have made substantive contributions to the research
or the manuscript. The exception is where funding was provided, which
should be included in Funding Sources. Please refer to the Guidelines
issued by the \href{http://www.icmje.org/}{ICMJE} to determine
non-author contributors that should be included in the acknowledgements.

\subsection{Ethics Statement}

{\label{573863}}

Karger Publishers is committed to publishing research that adheres to
the highest ethical standards and expects research to comply with the
appropriate guidelines for human studies~ and animal welfare regulations
. Copies of these guidelines and policy statements must be available for
review by the editors if necessary.

The Ethics Statement should be located after the Acknowledgement section
in the manuscript and state, as appropriate, that

\begin{itemize}
\tightlist
\item
  Subjects (or their parents or guardians) have given their written
  informed consent
\item
  The study protocol has been approved by the research institute's
  committee on human research
\item
  Animal experiments conform to internationally accepted standards and
  have been approved by the appropriate institutional review body
\end{itemize}

If the paper does not directly relate to human or animal research,
please include the statement ``The authors have no ethical conflicts to
disclose.''

\(^1\)\emph{Manuscripts reporting studies on human subjects
should include evidence that the research was conducted ethically in
accordance with the
\href{http://www.wma.net/en/30publications/10policies/b3/index.html}{World
Medical Association Declaration of Helsinki}. All patients should be
identified by numbers or aliases, not by their real names. For clinical
trials, registration in a public trials registry before or at the time
of first patient enrollment is a condition of consideration for
publication. The trial registration number must be provided upon
submission at the end of the manuscript.}

\(^2\)\emph{Manuscripts reporting studies on animal subjects
are encouraged to comply with the
\href{http://www.nc3rs.org.uk/arrive-guidelines}{Animal Research:
Reporting In Vivo Experiments} (ARRIVE) guidelines, developed by the
\href{http://www.nc3rs.org.uk/}{National Centre for the Replacement,
Refinement \& Reduction of Animals in Research} (NC3Rs). The name of the
Institutional Animal Care and Use Committee (IACUC) or equivalent ethics
committee(s), as well as relevant permit numbers, must be provided upon
submission at the end of the manuscript.}

\subsection{Disclosure Statement}

{\label{946680}}

Any financial interests (stocks, patents, employment, honoraria, or
royalties) or nonfinancial relationships (political, personal, or
professional) that may be interpreted to have influenced the manuscript
must be declared in the Disclosure Statement. If there is no conflict of
interest, please state ``The authors have no conflicts of interest to
declare ``.

\subsection{Funding Sources}

{\label{339323}}

Authors must give full details about the funding of any research
relevant to their study, including sponsor names and explanations of the
roles of these sources in the preparation of data or the manuscript.

\subsection{Author Contributions}

{\label{648288}}

In the Author Contributions section, a short statement detailing the
contributions of each person named as an author should be included. If
an author is removed or added to the manuscript after submission, an
explanation and a signed statement of agreement confirming the requested
change is required from all the initially listed authors and from the
author to be removed or added.

Contributors to the paper, who do not fulfill the
\href{http://www.icmje.org/recommendations/browse/roles-and-responsibilities/defining-the-role-of-authors-and-contributors.html}{ICMJE
authorship criteria}, should be credited in the Acknowledgement section.

\section{References (alphabetical)}

{\label{447794}}

The list of references should include only those publications which are
cited in the text in alphabetical order. Material submitted for
publication but not yet accepted may be cited in the text as
`unpublished data' but must not be included in the reference list. The
author's surname should be followed by their initials with no
punctuation other than a comma to separate individual authors.~
Preferably cite all authors (if not possible include at least 3 authors
followed by et al). More information on good referencing practice, as
well as further examples, can be found in
\href{https://www.ncbi.nlm.nih.gov/books/NBK7256/}{The National Library
of Medicine Style Guide for Authors}.~

Citations will be automatically formatted upon export according to the
journal style.

Citation:~\hyperref[csl:1]{[1]}

\section{Figure Legends}

{\label{310057}}

Fig. 1. Legend text.

Fig. 2. Legend text.

Please note that the figures themselves and all tables should be
uploaded separately. They do not constitute a part of the manuscript
file.

\selectlanguage{english}
\section*{References}\sloppy
\phantomsection
\label{csl:1}1. Sawant KV, Xu R, Cox R, Hawkins H, Sbrana E, Kolli D, Garofalo RP, Rajarathnam K (2015) {Chemokine {CXCL}1-Mediated Neutrophil Trafficking in the Lung: Role of {CXCR}2 Activation}. Journal of Innate Immunity 7:647–658

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