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\title{Genetics}



\author[1]{Josh Nicholson}%
\affil[1]{Authorea}%


\vspace{-1em}



  
  \date{April 25, 2026}


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\section*{Title Page}

{\label{868013}}

\textbf{Title:} A concise, informative title that avoids jargon and
includes the name of the organism under study,

\textbf{Authors Names:} For the authors' names, indicate different
affiliations with the superscript symbols: *, +, ++, \selectlanguage{ngerman}§. (These symbols
can be inserted using Microsoft Word.) After four authors, the symbols
double, triple, quadruple, etc., but in the same order ( **, \selectlanguage{english}+\selectlanguage{english}+, \selectlanguage{english}++\selectlanguage{english}++, SSSS)

Use a numbered footnote to indicate an author's present address.
Indicate a dedicatory footnote (if desired) with boldfaced type.

\textbf{Affiliations:} the authors' institutional affiliations,
including department; institution; and city, state or province, country
if outside the United States, and postal code (do not include districts
or street addresses).

\textbf{Reference numbers}: for data available in public repositories
and IRB numbers.

\pagebreak

\textbf{Running title:} of about 35 characters, including spaces,

\textbf{Keywords:} up to five key words or phrases

\textbf{Corresponding Author:} author's name, office mailing address
including street name and number, phone number, and email address.

\section*{Abstract}

{\label{224332}}

The abstract should be written for people who may not read the entire
paper, so it must stand on its own. The impression it makes usually
determines whether the reader will go on to read the article, so the
abstract must be engaging, clear, and concise. In addition, the abstract
may be the only part of the article that is indexed in databases, so it
must accurately reflect the content of the article. A well-written
abstract is THE most effective way to reach intended readers, leading to
more robust search, retrieval, and usage of the article. Your abstract
should:

\begin{itemize}
\tightlist
\item
  provide a synopsis of the entire article;
\item
  begin with the broad context of the study, followed by specific
  background for the study;
\item
  describe the purpose, methods and procedures, core findings and
  results, and conclusions of the study;
\item
  emphasize new or important aspects of the research;
\item
  engage the broad readership of GENETICS and be understandable to a
  diverse audience (avoid using jargon);
\item
  be a single paragraph of less than 250 words;
\item
  contain the full name of the organism studied;
\item
  NOT contain citations or abbreviations.
\end{itemize}

\section*{Introduction}

{\label{700094}}

For the introduction, authors should be mindful of the broad readership
of the journal. The introduction should set the stage for the importance
of the work to a generalist reader and draw the reader in to the
specific study. The scope and impact of the work should be clearly
stated.

In individual organisms where a mutant is being studied, the rationale
for the study of that mutant must be clear to a geneticist not studying
that particular organism. Similarly, study of particular phenotypes
should be justified broadly and not on the basis of interest for that
organism alone. General background on the importance of the genetic
pathway and/or phenotype should be provided in a single, well-reasoned
paragraph near the beginning of the introduction.

Authors are encouraged to:

\begin{itemize}
\tightlist
\item
  cite the supporting literature completely rather than select a subset
  of citations;
\item
  provide important background citations, including relevant review
  papers (to help orient the non-specialist reader);
\item
  to cite similar work in other organisms.
\end{itemize}

\section*{Materials and Methods}

{\label{463887}}

Manuscripts submitted to GENETICS should contain a clear description of
the experimental design in sufficient detail so that the experimental
analysis could be repeated by another scientist. If the level of detail
necessary to explain the protocol goes beyond two paragraphs, give a
short description in the main body of the paper and prepare a detailed
description for supporting information. GENETICS suggests authors
supplement their methods with detailed protocols on the open access
repository protocols.io.

\emph{For example:} indicate how many individuals were used, and if
applicable how individuals or groups were combined for analysis. If
working with mutants indicate how many independent mutants were
isolated. If working with populations indicate how samples were
collected and whether they were random with respect to the target
population.

\subsection*{Statistical Analysis}

{\label{402544}}

It is important to indicate what statistical analysis has been
performed; not just the name of the software and options selected, but
the method and model applied. In the case of many genes being examined
simultaneously, or many phenotypes, a multiple comparison correction
should be used to control the type I error rate, or a rationale for not
applying a correction must be provided. The type of correction applied
should be clearly stated. It should also be clear whether the p-values
reported are raw, or after correction. Corrected p-values are often
appropriate, but raw p-values should be available in the supporting
materials so that others may perform their own corrections. In large
scale data exploration studies (e.g. genome wide expression studies) a
clear and complete description of the replication structure must be
provided.

\subsection*{Data Availability}

{\label{508939}}

At the end of the Materials and Methods section, include a statement on
reagent and data availability. Please read the
\href{http://www.genetics.org/content/scope-and-publication-policies\#data-reagent}{Data
and Reagent Policy} before writing the statement. Make sure to list the
accession numbers or DOIs of any data you have placed in public
repositories. List the file names and descriptions of any data you will
upload as supplemental information. The statement should also include
any applicable IRB numbers. You may include specifications for how to
properly acknowledge or cite the data. **Please note that for the review
process you agree to make data available upon request. If accession
numbers/DOIs are not available yet, please indicate where data will be
submitted. Accession numbers/DOIs must be available prior to
publication.

\emph{For example:} Strains are available upon request. File S1 contains
detailed descriptions of all supplemental files. File S2 contains SNP ID
numbers and locations. File S3 contains genotypes for each individual.
Sequence data are available at GenBank and the accession numbers are
listed in File S3. Gene expression data are available at GEO with the
accession number: GDS1234. Code used to generate the simulated data is
provided in file S4.

\section*{Results and Discussion}

{\label{732872}}

The results and discussion should not be repetitive. The results section
should give a factual presentation of the data and all tables and
figures should be referenced; the discussion should not summarize the
results but provide an interpretation of the results, and should clearly
delineate between the findings of the particular study and the possible
impact of those findings in a larger context. Authors are encouraged to
cite recent work relevant to their interpretations. Present and discuss
results only once, not in both the Results and Discussion sections. It
is sometimes acceptable to combine results and discussion. The text
should be as succinct as possible. Heed Strunk and White's dictum:
``Omit needless words!''

Example citation~\hyperref[csl:1]{(Casillas and Barbadilla 2017)}.

The text should conform to the style in recent issues of GENETICS.
Please follow these guidelines:

\emph{In-text citations}: Include both names for citations with two
authors. Citations with three or more authors name the first author with
et al. for the other authors. Cite only articles that are published or
in press. To cite personal communications or unpublished results, list
all contributors by initials and last name; do not use et al..

Numbers: In the text, write out numbers nine or less except as part of a
date, a fraction or decimal, a percentage, or a unit of measurement. Use
Arabic numbers for those larger than nine, except as the first word of a
sentence; however, try to avoid starting a sentence with such a number.

Units: Use abbreviations of the customary units of measurement only when
they are preceded by a number: ``3 min'' but ``several minutes''. Write
``percent'' as one word, except when used with a number: ``several
percent'' but ``75\%.'' To indicate temperature in centigrade, use deg
(for example, 37deg); include a letter after the degree symbol only when
some other scale is intended (for example, 45degK).

Nomenclature and Italicization: Italicize names of organisms even when
when the species is not indicated. Italicize the first three letters of
the names of restriction enzyme cleavage sites, as in HindIII. Write the
names of strains in roman except when incorporating specific genotypic
designations. Italicize genotype names and symbols, including all
components of alleles, but not when the name of a gene is the same as
the name of an enzyme. Do not use ``+'' to indicate wild type. Carefully
distinguish between genotype (italicized) and phenotype (not italicized)
in both the writing and the symbolism.

To divide the text into sections, only these four levels are allowed:

Level 1: Centered, all capital letters. Use this level for major
sections of text, such as Materials and Methods and the Discussion.

Level 2: Freestanding flush-left boldface. Use this level only to group
two or more closely related Level 3 headings in long article.

Level 3: Paragraph-initiating boldface, followed by a colon.

Level 4: Paragraph-initiating italic. Level 4 headings may be numbered,
but only when the numbers must be cited in the text.

\selectlanguage{english}
\FloatBarrier
\section*{References}\sloppy
\phantomsection
\label{csl:1}Casillas S., and A. Barbadilla, 2017 {Molecular Population Genetics}. Genetics 205: 1003–1035. \url{https://doi.org/10.1534/genetics.116.196493}

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