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\begin{document}
\begin{CJK}{UTF8}{gbsn}

\title{Cancer Discovery - Research Article}



\author[1]{Josh Nicholson}%
\affil[1]{Authorea}%


\vspace{-1em}



  
  \date{April 25, 2026}


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\selectlanguage{english}
\begin{abstract}
{This Authorea document template can be used to prepare documents
according to a desired citation style and authoring guidelines.
Abstracts are not always required, but most academic papers have one and
writers should know how to produce a useful abstract. An abstract should
be a very short, clear and concise summation of the entire paper. An
abstract should provide enough of a preview that a typical reader will
know whether or not they wish to read the paper. It should reveal both
the purpose and conclusions of the paper.}\\%
\end{abstract}%



\sloppy


\section*{Research Articles}

{\label{651000}}

Research Articles report on original studies with broad impact across
the fields of basic, translational, clinical, and epidemiologic cancer
research as well as cancer prevention research. These articles should be
of exceptional significance to a diverse audience of cancer researchers
and scientists.

\begin{itemize}
\tightlist
\item
  150-word abstract
\item
  50-word statement of significance
\item
  6,000 words of text
\item
  50 references
\item
  7 figures and/or tables total (no panel limit; each figure or table
  must fit on a single printed page)
\item
  Sections should be arranged in the following order: title page,
  abstract, statement of significance, introduction, results,
  discussion, methods, references, tables, table legends, figure
  legends, and figures
\item
  Results and Discussion sections must not be combined
\end{itemize}

\par\null

\section*{Abstract}\label{abstract}

The abstract must be concise, yet should accurately outline the content
of the manuscript (see the Categories of Articles page of each journal
for abstract length requirements for each type of article). Because
these abstracts are used by secondary services (e.g., MEDLINE, Chemical
Abstracts, Web of Science, Scopus), they should recapitulate in
abbreviated form the purpose of the study and the experimental
technique, results, and data interpretations. Data such as the number of
test subjects and controls, strains of animals or viruses, drug dosages
and routes of administration, tumor yields and latent periods, length of
observation period, and magnitude of activity should be included. Vague,
general statements such as ``The significance of the results is
discussed'' or ``Some physical properties were studied'' should be
avoided. Important terms relevant to the content of the manuscript
should be incorporated into the abstract to assist indexers and
searchers. Abbreviations should be kept to an absolute minimum; however,
if they are needed, they must be explained at first mention within the
abstract so that it can be understood as an independent unit from the
remainder of the manuscript. Do not cite references in the abstract.

\section*{Introduction}\label{introduction}

The introduction should provide a brief overview of the background and
rationale for the study. It is not necessary to cite all of the
background literature in the introduction. Brief reference to the most
pertinent articles generally suffices to acquaint the reader with the
findings of others in the field and with the problem or question that
the investigation addresses. Sample citation~\hyperref[csl:1]{(1)}.

\section*{Materials and Methods}\label{materials-and-methods}

Explanation of the experimental methods should be adequate for
repetition by qualified investigators. Procedures that have been
described in previous publications should not be described in detail but
merely cited with appropriate references along with any modifications of
the procedure. Only new and substantial modifications of previously
published procedures need complete exposition. The sources of special
chemicals or preparations used should be provided. Any commercial
products that are mentioned should include the name of the manufacturer
and catalog numbers.

\section*{Results}\label{results}

Include a concise summary of the data presented in all display items
(figures and tables). Excessive elaboration of data shown in display
items should be avoided.

\section*{Discussion}\label{discussion}

The data should be interpreted concisely without repeating material
already presented in the Results section. Speculation is permissible,
but it must be well founded, and discussion of the wider implications of
the findings is encouraged.

\section*{Acknowledgments}\label{acknowledgments}

Include the names of others contributing to the work who are not
identified as authors.

\selectlanguage{english}
\FloatBarrier
\section*{References}\sloppy
\phantomsection
\label{csl:1}1. Pauli C, Hopkins BD, Prandi D, Shaw R, Fedrizzi T, Sboner A, et al. {Personalized In Vitro and In Vivo Cancer Models to Guide Precision Medicine}. Cancer Discovery [Internet]. American Association for Cancer Research ({AACR}); 2017;7:462–77. Retrieved from: \url{https://doi.org/10.1158\%2F2159-8290.cd-16-1154}

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