We encourage authors to submit supplemental material that enhances the published manuscript and which may be of interest to other investigators. Examples include tables figures movies and extended Materials and Methods sections. Enough detail must be provided between the text and the supporting information for the complete replication of the work by an independent scientist. In addition authors are encouraged to provide information that may aid in the use of the results of the paper for additional studies. For example in eQTL studies the data needed to produce the summary cis and trans plot provides detailed information that another scientist seeking to understand what genes may be regulating their favorite gene may find extremely useful. Any information which enhances the impact and usefulness of the work presented is appropriate for the supplement. Other examples include complete analysis results (including those not statistically significant) for microarray analyses metabolomic data or phenotypic data.