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\begin{document}

\title{Bioessays Article Template ~ ~ ~\\}


 \author{The Authorea Team}


\date{}

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\textbf{Title:}~Describe the topic simply and engagingly. State the main
point of the paper in the title, using good keywords. The title should
not exceed~17 words.\\

\textbf{Subtitle:}~In no more than~20 words, describe the main insight
that is presented in the manuscript.\\

For further reading on how to optimise your title (with some examples),
please
click~\href{http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1521-1878/homepage/good_titles.pdf}{here.}\\

\textbf{Summary (Abstract)}

The limit for the abstract is~150 words, and no citations are allowed.
Some of our rubrics do not have summaries (abstracts). Please chek out
our~\href{http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1521-1878/homepage/author_guide_rubrics.pdf}{rubric
guide}~first. Place your most important and new concepts or insights
first in the summary, not in the middle. Do not begin with an old and
well-known fact (e.g. ``The sequencing of the human genome has produced
huge quantities of data\ldots{}''). End the summary with a
forward-looking perspective, if possible.\\

Important:~The article summary is the only piece (apart from the title)
that potential reviewers read before accepting or declining the
invitation to review! The summary should be extremely well written and
structured, clearly presenting the main new insight of the manuscript
early, and in an appealing way.\\

For more information on writing good abstracts, please
click~\href{http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1521-1878/homepage/good_abstracts.pdf}{here}.\\

\textbf{Introduction}

The Introduction should not exceed~1000 words. Some of our rubrics do
not have a section headed ``Introduction''. Please chek out
our~\href{http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1521-1878/homepage/author_guide_rubrics.pdf}{rubric
guide}~first. Give a concise introduction suitable for a broad audience
and not an exhaustive list of highly field-specific information and
abbreviations. Those should instead be extracted and condensed into one
or more tables or information boxes (see below).\\

\textbf{Conclusions}

Please do not use more than~300 words~for your conclusions. Some of our
rubrics do not have a section headed ``Conclusions''. Please chek out
our~\href{http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1521-1878/homepage/author_guide_rubrics.pdf}{rubric
guide}~first. Condense the main points of the article, and present
implications, consequences for new understanding and future
perspectives. Head this section ``Conclusions'' or ``Conclusions and
prospects''.\\

\textbf{Tables and information boxes}

Specialized parts of the text can be condensed into information boxes.
However, these boxes should not exceed 1 page each. Highly structured
information (e.g. gene names and regulators, proteins and ligands, etc.)
can be summarised in tabular format. Boxes/tables should be referenced
from the text where appropriate. If vital for immediate understanding of
the article, an information box/table can be placed immediately after
the introduction. Please bear in mind the limit of~6
figures/tables/boxes per article~and reserve enough of these for the
things you really want readers to understand. (Exceptions: only 2
figures/tables/boxes are allowed for the following rubrics: Ex
laboratorio, Ideas \& Speculations, Commentary and Book reviews.) For
more information, please
click~\href{http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1521-1878/homepage/good_tables_and_infoboxes.pdf}{here}.\\

\textbf{Figures and photographs}

Appropriate use of figures/illustrations and photos to explain
complicated concepts or the object of discussion is welcome. A total of
6 is permitted. (Exceptions: only 2 figures/tables/boxes are allowed for
the following rubrics: Ex laboratorio, Ideas \& Speculations, Commentary
and Book reviews.) To ensure good print quality, your figures should be
submitted preferably in~PPT (Power Point) or TIFformat with a resolution
of~800 dpi, or as close to this resolution as possible. In the case of
diagrams with lettering (e.g. figures created in Adobe Illustrator) PPT,
DOC (Word file) or EPS format should be submitted. Colour figures must
be submitted in~RGB~colourspace. Please do not submit as CMYK.
Unacceptable figure formats are: PDF, GIF, PSD, CRD, PCT, XLS, BMP, 123
(or other Lotus formats). Lines and lettering must be large and dense
enough to remain legible after the figure is reduced. Text in figures
must not be smaller than 6-point Helvetica. Avoid strongly coloured/dark
backgrounds. Figure parts should be labelled in capital letters followed
by a bracket, e.g. A), B), C). Figures should be referred to in
sequence, using ``Fig. 1A'' or ``Figs. 1,2'' etc.\\

Please
click~\href{http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1521-1878/homepage/good_figures.pdf}{here}~for
useful tips on how to improve your figures (including some examples).\\

\textbf{Citations and reference list}

Depending on
the~\href{http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1521-1878/homepage/author_guide_rubrics.pdf}{rubric},
reference lists should not exceed~120 or 30~entries.Citation of
published literature should be indicated by numbers in square brackets
at normal text level (not superscript), e.g. ``This study {[}12{]}
showed that \ldots{}''. Reference list entries should comply with the
examples below. Journal titles should be abbreviated in accordance with
the USA National Standard abbreviations for journals. For easier
formatting of your reference list, get
the~\href{http://endnote.com/styles/BioEssays.ens}{Endnote file}.\\

\textbf{Borikova AL, Dibble CF, Sciaky N, WelchCM,}~et al. 2010. Rho
kinase inhibition rescues the endothelial cell cerebral cavernous
malformation phenotype.~\emph{J Biol Chem}~\textbf{285:}~11760-4.\\

\textbf{Perreten V, Frey J.}~2009. Use of a microchip to detect
antibiotic resistance genes in~\emph{Bacillus anthracis}. In Kostic T,
Butaye P, SchrenzelJ. ed;~\emph{Detection of highly dangerous
pathogens}. Wiley-VCH. p 147-152.\\

If there are more than 4 authors on a paper, use ``et al.'' for the
remainder.

Inclusion and citation of unpublished work:~This should be kept to a
minimum (no more than 2 such citations are permissible). Your own
unpublished observations, including results submitted for publication,
should be cited as such in the text only, and not in the reference list.
Personal communications, i.e. unpublished observations of other
scientists, should only be included with written permission from the
source.\\

\textbf{Keywords and abbreviations}

\textbf{Kewords:}~Please provide up to 7 keywords/terms that you feel
optimally describe the topic(s) of your paper.\\

\textbf{Abbreviations:}~Very common abbreviations such as DNA, RNA, PCR
do not need explaining. However, BioEssays' readership is very broad, so
abbreviations such as SNP (single nucleotide polymorphism) or GPCR
(G-protein coupled receptor) should be included in an abbreviations
section. All abbreviations that are highly field-specific should be
explained in such a section. Gene names need not be included in the
abbreviations section, as the full names are often no more informative
than the abbreviations. In cases where an abbreviation is used only once
or twice in short succession, it need not be included in the list of
abbreviations: it is enough to give the full term in the text.\\

\textbf{Nomenclature and style}

For biochemical nomenclature, refer to the No. 1 issue of
the~\emph{Journal of Biological Chemistry}. EC numbers should accompany
citation of all enzymes. SI units should be used throughout in
preparation of manuscripts. Genetics nomenclature should follow that
used by the Journal~\emph{Genetics}. Gene and species names should be
in~\emph{italic}~type. Proteins should be in roman type.\\

\textbf{Supporting information}

Supporting Information can be a useful way to include important but
ancillary information with the online version of an article. Examples of
Supporting Information include additional tables, data sets, figures,
movie files, audio clips, 3D structures, and other related nonessential
multimedia files. Supporting Information should be cited within the
article text, and a descriptive legend should be included. It is
published as supplied by the author, and a proof is not made available
prior to publication; for these reasons, authors should provide any
Supporting Information in the desired final format. For further
information on recommended file types and requirements for submission,
please
visit:~\href{http://authorservices.wiley.com/bauthor/suppinfo.asp}{The
supporting information page in Author Services}.

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