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\begin{document}

\title{Immunity Article Template\\}


 \author{The Authorea Team}


\date{}

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\subsubsection*{\texorpdfstring{Title\\
}{Title }}\label{title}

Titles can occupy no more than three lines of type. Each line should
contain no more than 50 characters, including spaces. The title should
convey the conceptual significance of the paper to a broad readership.\\

\subsubsection*{\texorpdfstring{Authors/Affiliations\\
}{Authors/Affiliations }}\label{authorsaffiliations}

Author names should be spelled out rather than set in initials. Authors
should be footnoted to corresponding affiliations. Affiliations should
contain the following core information: department(s)/subunit(s);
institution; city, state/region, postal code; country.~Note: Please
check author names and affiliations carefully, as we cannot amend or
correct these sections after publication.\\

\subsubsection*{\texorpdfstring{Corresponding Author\\
}{Corresponding Author }}\label{corresponding-author}

The ``Correspondence'' line should include the e-mail address(es) of the
corresponding author(s). One corresponding author is preferred for
reasons stated in the Authorship section of Editorial Policies above.
But there is no mandatory limit on the number of corresponding authors
that may be listed.~Corresponding authors may also provide a Twitter
handle as a secondary means of contact. Please see the corresponding
author responsibilities noted above in the Editorial Policies.\\

\subsubsection*{\texorpdfstring{Lead Contact\\
}{Lead Contact }}\label{lead-contact}

Every author list must identify one corresponding author as a Lead
Contact, noted by a footnote in the manuscript. If there is only one
corresponding author, that author will be listed as the Lead Contact.
Please see the Lead Contact responsibilities noted above in the
Authorship section of the Editorial Policies.\\

\subsubsection*{\texorpdfstring{Additional Footnotes\\
}{Additional Footnotes }}\label{additional-footnotes}

Footnotes are only allowed on page 1 of the text (and in tables). They
may include a Lead Contact (mandatory) or a present address (optional),
or they may indicate co-first authorship (optional).~For more on
designations of author contributions, please see the ``Authorship''
section above, under Editorial Policies.\\

\subsubsection*{\texorpdfstring{Summary\\
}{Summary }}\label{summary}

The Summary consists of a single paragraph of fewer than 150 words. It
should clearly convey the conceptual advance and significance of the
work to a broad readership. In particular, the Summary should contain a
brief background of the question, a description of the results without
extensive experimental detail, and a summary of the significance of the
findings. References should not be cited in the Summary.\\

\subsubsection*{\texorpdfstring{Keywords\\
}{Keywords }}\label{keywords}

Authors are encouraged to include up to ten keywords that will be
associated with the article on Cell Press platforms and on PubMed. These
keywords should be listed in the manuscript after the Summary, separated
by commas.\\

\subsubsection*{\texorpdfstring{Highlights and eTOC Blurb\\
}{Highlights and eTOC Blurb }}\label{highlights-and-etoc-blurb}

Highlights are a short collection of bullet points that convey the core
findings of the article.~\emph{Specifications}: up to four bullet points
may be included; the length of an individual bullet point should not
exceed 85 characters (including spaces); only the core results of the
paper should be covered.\\

The eTOC blurb is a short summary of the main take-home message of the
paper and should describe the context and significance of the findings
for the broader readership. Please see the ``In Brief'' links in the
Table of Contents for examples.~\emph{Specifications}: This blurb should
be 50 words or fewer; this blurb should be written in the third person
and refer to ``First Author et al.''\\

Both are required for all research papers and will be displayed online
with the article; however, they will not appear in print. On the EM page
where you are asked to upload your files, please choose ``Highlights and
eTOC Blurb'' and upload a single Word document containing both your
Highlights and the eTOC Blurb.\\

\subsubsection*{\texorpdfstring{Introduction\\
}{Introduction }}\label{introduction}

The Introduction should be succinct, with no subheadings, and should
present the background information necessary to provide a biological
context for the results.\\

\subsubsection*{\texorpdfstring{Results\\
}{Results }}\label{results}

This section should be divided with subheadings. Footnotes should not be
used.\\

\subsubsection*{\texorpdfstring{Discussion\\
}{Discussion }}\label{discussion}

The Discussion should explain the significance of the results and place
them into a broader context. It should not be redundant with the Results
section. This section may contain subheadings and can in some cases be
combined with the Results section.\\

\subsubsection*{\texorpdfstring{Experimental Procedures\\
}{Experimental Procedures }}\label{experimental-procedures}

The Experimental Procedures should, at minimum, include enough detail to
allow the reader to understand the general experimental design and to be
able to assess the data presented in the figures. More detailed
protocols and procedures needed for readers to reproduce experiments
should be included in the Supplemental Experimental Procedures. Any
supplemental tables that list materials used in the study
(oligonucleotides, strains, etc.) should be included within the relevant
section of the Supplemental Experimental Procedures; these tables should
have a title but should not be numbered. If your paper contains
Supplemental Experimental Procedures, please make sure that they are
referred to within the main Experimental Procedures so that it is clear
to the reader that additional details are available online. ~ This
section should also include a description of any statistical methods
employed in the study. A more detailed version of the procedures and
details such as oligo sequences, strains, and specifics of how
constructs were made can be included in the Supplemental Information,
but it is not appropriate to move the majority of the Experimental
Procedures to Supplemental Information in order to shorten the text.
Please see our
complete~\href{http://www.cell.com/supplemental-information}{Supplemental
Information~guidelines}~for more information.\\

\subsubsection*{\texorpdfstring{Author Contributions\\
}{Author Contributions }}\label{author-contributions}

For primary research papers, we ask you to include a dedicated Author
Contributions section preceding the Acknowledgments to give information
about individual author contributions to the work. Please keep this
section as concise as possible and use initials to indicate author
identity. All of the authors listed on the paper should be mentioned in
this section at least once. We are happy for you to use a traditional
format such as ``A.B. and C.D. conducted the experiments, E.F. designed
the experiments and wrote the paper\ldots{}'' but would also encourage
you to
use~\href{http://www.cell.com/pb/assets/raw/shared/guidelines/CRediT-taxonomy.pdf}{the
CRediT taxonomy}~instead.\\

\subsubsection*{\texorpdfstring{Acknowledgments\\
}{Acknowledgments }}\label{acknowledgments}

This section may acknowledge contributions from non-authors and/or list
funding sources, and it should include a statement of any conflicts of
interest.~Please check this section carefully, as we cannot allow
amendments or corrections after publication.\\

\subsubsection*{\texorpdfstring{References\\
}{References }}\label{references}

References should include only articles that are published or in press.
For references to in press articles, please confirm with the cited
journal that the article is in fact accepted and in press and include a
DOI number and online publication date. Unpublished data, submitted
manuscripts, abstracts, and personal communications should be cited
within the text only. Personal communication should be documented by a
letter of permission. Submitted articles should be cited as unpublished
data, data not shown, or personal communication.\\

In-text citations should be written in Harvard style and not numbered,
e.g., ``Smith et al., 2015; Smith and Jones, 2015.''\\

Please use the style shown below for references. Note that ``et al.''
should only be used after ten authors.\\

\textbf{Article in a periodical:}\\

Sondheimer, N., and Lindquist, S. (2000). Rnq1: an epigenetic modifier
of protein function in yeast. Mol. Cell~\emph{5}, 163--172.\\

\textbf{Article in a book:}\\

King, S.M. (2003). Dynein motors: Structure, mechanochemistry and
regulation. In Molecular Motors, M. Schliwa, ed. (Weinheim, Germany:
Wiley-VCH Verlag GmbH), pp. 45--78.\\

\textbf{An entire book:}\\

Cowan, W.M., Jessell, T.M., and Zipursky, S.L. (1997). Molecular and
Cellular Approaches to Neural Development (New York: Oxford University
Press).\\

\subsubsection*{\texorpdfstring{Figure Legends\\
}{Figure Legends }}\label{figure-legends}

Legends should be included in the submitted manuscript as a separate
section. Each figure legend should have a brief title that describes the
entire figure without citing specific panels, followed by a description
of each panel. For any figures presenting pooled data, the measures
should be defined in the figure legends (for example, ``Data are
represented as mean \selectlanguage{ngerman}± SEM.''). Each legend should refer to any
supporting items in the Supplemental Information (e.g., ``See also
Figure S1.'').\\

\subsubsection*{\texorpdfstring{Tables\\
}{Tables }}\label{tables}

When creating a table, please use the Microsoft Word Table function.
Tables should include a title, and footnotes and/or legend should be
concise. Include tables in the submitted manuscript as a separate
section. Tables not created with the Microsoft Word table function will
need to be revised by the author.\\

When creating tables, please adhere to the following guidelines:\\

\begin{itemize}
\tightlist
\item
  Do not submit tables in Excel or PDF format. Do not place an Excel
  table in a Word document.\\
  \hspace*{0.333em}\\
\item
  Format tables with Word's Table function; do not use tabs or spaces to
  create a table.\\
  \hspace*{0.333em}\\
\item
  Do not use line breaks or spaces to separate data within a cell. Use
  separate cells for all discrete data elements within a table.\\
  \hspace*{0.333em}\\
\item
  Number tables as Table 1, Table 2, Table 3, etc., rather than as Table
  1a, Table 1b, Table 1c, etc.\\
  \hspace*{0.333em}\\
\item
  If bold or italic font is used within a table to indicate some feature
  of the data, please give an explanation of its usage in the legend.\\
  \hspace*{0.333em}\\
\item
  All abbreviations within a table must be defined in the table legend
  or footnotes.\\
  \hspace*{0.333em}\\
\item
  Footnotes should be listed with superscript lowercase letters,
  beginning with ``a.'' Footnotes may not be listed with numbers or
  symbols.\\
  \hspace*{0.333em}\\
\end{itemize}

\subsubsection*{\texorpdfstring{Supplemental Information\\
}{Supplemental Information }}\label{supplemental-information}

In general, Supplemental Information is limited to data and other
materials that directly support the main conclusions of a paper but
cannot be included in the main paper for reasons such as space or file
format restrictions. SI should not be used to present data that are
preliminary or that conceptually go beyond the main point of the
paper.\\

Before submitting your supplemental materials, please refer to our
complete instructions in
the~\href{http://www.cell.com/supplemental-information}{Supplemental
Information guidelines}. This page also contains information on
submitting movie and other multimedia files.\\

\subsection*{\texorpdfstring{Figures and Graphical Abstracts\\
}{Figures and Graphical Abstracts }}\label{figures-and-graphical-abstracts}

Digital figure files submitted
through~\href{http://www.editorialmanager.com/immunity/?__hstc=25856994.aadc40902d970d22758a35bbc04a125f.1464096900346.1468437019447.1469466741155.11\&__hssc=25856994.2.1469466741155\&__hsfp=13480855}{Editorial
Manager}~must conform to
our~\href{http://www.cell.com/figureguidelines}{digital figure
guidelines}~or authors will be asked to revise them.\\

If you have any questions about digital files, please contact Calen
Rubin, Managing Editor of~\emph{Immunity},
at~\href{mailto:crubin@cell.com}{\nolinkurl{crubin@cell.com}}.~\\

\subsubsection*{\texorpdfstring{Graphical Abstract\\
}{Graphical Abstract }}\label{graphical-abstract}

A graphical abstract should allow readers to quickly gain an
understanding of the main take-home message of the paper and is intended
to encourage browsing, promote interdisciplinary scholarship, and help
readers identify more quickly which papers are most relevant to their
research interests. Examples of this feature can be seen in the online
version of articles published in~\emph{Immunity~}from January 2010
onwards. Graphical abstracts may be submitted at any stage but are only
required once a paper has been accepted for publication (it is not
necessary to provide a graphical abstract for a new submission).
Graphical abstracts can be uploaded
in~\href{http://www.editorialmanager.com/immunity/?__hstc=25856994.aadc40902d970d22758a35bbc04a125f.1464096900346.1468437019447.1469466741155.11\&__hssc=25856994.2.1469466741155\&__hsfp=13480855}{Editorial
Manager}~by selecting ``Graphical Abstract'' when uploading files.~Refer
to our~\href{http://www.cell.com/figureguidelines}{digital figure
guidelines}~for graphical abstract preparation details.

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