With increasing numbers of older adults worldwide, multimorbidity and polypharmacy are on the rise, highlighting the risks of potential drug-drug interactions (pDDIs). As cardiovascular agents are among the most prescribed medications, we performed an observational cross-sectional study to determine the prevalence of pDDIs in a cardiology department of a secondary hospital. Patient data was obtained from medical records and screened for pDDIs using the Micromedex drug interaction software. Descriptive statistics, Chi-square (χ2) test, Student’s t test and Pearson’s correlation test were used to analyse the results. Out of 50 participants, 45 (90%) had at least one pDDI. A total of 266 pDDIs were identified, with more than half classified as major. At least one major pDDI was found in 78% of patients. 42% of patients were at an increased risk of bleeding due to pDDIs. A statistically significant relationship was found between the detection of pDDIs and both patient age (p = 0.005) and the number of drugs used (p < 0.001). Our findings pose questions about the wider prevalence and risks of pDDIs among patients with cardiovascular disease.