Summary Background: The distribution pattern of central tarsal bone (CTB) changes has not been described, except for slab- and dorsomedial-plantarolateral fractures. Objectives: The goal was to describe CTB changes in CT, their distribution and associations, hypothesizing that changes occur mainly dorsomedially and that most fissure/fractures are linked to demineralization. Study design: Retrospective Methods: Standing and recumbent tarsal CTs from 94 clinical cases were retrospectively evaluated. Besides general case information, degree of sclerosis (none-severe), lesions (demineralization, cystoid, fissure/fracture) and their location were recorded dividing CTBs in 8 regions. Results: 85/94 tarsi showed at least one region of moderate to severe sclerosis, with 90% affecting the dorsomedial region. The prevalence of lesions was significantly associated with higher degrees of sclerosis (p=0.037) at this site. Of 32 demineralizing lesions, 21 were in the proximal subchondral bone dorsomedially. 24 CTBs showed fissures/fractures and 19/24 were in a dorsomedial-plantarolateral direction, mostly associated with demineralization (17/19). Of 5 fissures/fractures with different configurations, none had associated demineralization. There were 27 cyst-like lesions, 21/27 in the distal subchondral bone and almost half (13/27) were located medially. Main limitations: Retrospective nature; heterogeneous, warmblood oriented, population; no clinical correlation of findings nor histologic confirmation of described changes . Conclusions: Given the links between sclerosis, demineralization and fissures/fractures, the dorsomedial proximal subchondral bone plate of the CTB must be scrutinized both in CT and radiography.