Nitrofurantoin is an antibiotic used for treating and preventing urinary tract infections (UTIs). However, major and rare adverse effect of nitrofurantoin induced pulmonary eosinophilia (NIPE), serious condition causes abnormal white blood cell and Immunoglobulin E (IgE) buildup in the lungs, leading to cough, shortness of breath, and fatigue was seen in a patient. This case report describes a patient who developed symptoms of cough, dyspnea, and fatigue after receiving nitrofurantoin for a urinary tract infection over time. Overall, nitrofurantoin is valuable for UTI treatment, but clinicians should be mindful of its adverse effects and adjust doses accordingly.