This study utilizes integrated innovative approaches in machine learning modeling to analyze the Earth’s surface and examine urban expansion resulting from human activity, focusing on land use/land cover (LULC) changes in the Mashhad Metropolitan Area (MMA) from 1990 to 2020, with predictions for 2030. Advanced algorithms, including support vector machines (SVMs), Multilayer Perceptron (MLP) neural network, and Markov chains, were employed in the analysis. The results indicate that from 1990 to 2010, built-up areas increased by 51.70%, green spaces by 26.40%, while sand-covered areas decreased by 36.49%. From 2010 to 2020, the growth rate for built-up areas and green spaces slowed, with built-up areas growing by 13.27% and green spaces by 12.29%. The findings project a 15.59% increase in built-up areas and a 6.44% decrease in green spaces by 2030. Model validation was conducted using the Area Under the Curve (AUC) of 0.767 and Kappa coefficient of 0.7589, indicating strong model validity. Furthermore, this research identifies critical factors influencing LULC changes, revealing that the distance from green spaces and proximity to built-up areas are the most significant determinants. By addressing a significant gap in understanding the impact of human activities on urban dynamics and their ecological implications in developing regions such as the MMA, this study contributes meaningfully to urban planning.