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Effects of race, ethnicity and socioeconomic deprivation on postpartum haemorrhage in high-income countries: A systematic review and meta-analysis
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  • Amy Elsmore,
  • Gbenga Alayande,
  • Elizabeth Mainwaring,
  • Mahfam Jafarpour,
  • Michael Rimmer,
  • Neil Cockburn,
  • Jason Curtis,
  • Ragave Ilaalagan,
  • Bassel H.AL WATTAR,
  • Sarah Bell,
  • Bala Karunakaran,
  • William Parry-Smith,
  • Pensee Wu
Amy Elsmore
Princess Royal Hospital

Corresponding Author:a.c.elsmore@keele.ac.uk

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Gbenga Alayande
Royal Wolverhampton Hospitals NHS Trust
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Elizabeth Mainwaring
University of Cambridge School of Clinical Medicine
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Mahfam Jafarpour
Keele University Faculty of Medicine & Health Sciences
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Michael Rimmer
The University of Edinburgh MRC Centre for Reproductive Health
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Neil Cockburn
University of Birmingham
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Jason Curtis
Shrewsbury and Telford Hospital NHS Trust
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Ragave Ilaalagan
Princess Royal Hospital
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Bassel H.AL WATTAR
Anglia Ruskin University Clinical Trials Unit
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Sarah Bell
NHS Wales Cardiff and Vale University Health Board
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Bala Karunakaran
Princess Royal Hospital
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William Parry-Smith
Princess Royal Hospital
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Pensee Wu
Keele University Faculty of Medicine & Health Sciences
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Abstract

Abstract Background Postpartum haemorrhage (PPH) is a leading cause of mortality and morbidity globally. While studies have revealed disparities in maternal and fetal outcomes, disparities in PPH risk within diverse populations remains understudied. Objectives To quantify the association between maternal race, ethnicity, deprivation and the risk of PPH in High Income Countries (HIC’s). Search strategy A systematic search of MEDLINE, CINAHL, EMBASE and Google Scholar from inception to 20 th August 2024. Selection criteria Observational and experimental studies from HICs that reported the outcome of PPH, in at least two racial, ethnic or socioeconomic groups. Data collection and analysis Two reviewers performed independent data extraction. Random-effects model was used to estimate risk. Subgroup analysis was performed by geographical region and time period. Main results 79 studies with 169,579,388 women were included. Women from an ethnic minority background had an increased risk of PPH, compared to White women. This effect was seen across Black women (OR 1.16, 95% CI 1.09,1.23), Asian women (OR 1.33, 95% CI 1.27, 1.39), Hispanic women (OR 1.20, 95%CI 1.12, 1.29), and women from the minority ethnic group within a given study (OR 1.13 95% CI 1.03,1.24). Eight studies reporting PPH per socioeconomic group reported increased risk of PPH for those living in socioeconomic deprivation. Conclusions Women from an ethnic minority background or exposed to socioeconomic deprivation had an increased risk of PPH in high income settings. Standardisation of data collection on ethnicity, race and socioeconomic status is crucial for future research to accurately quantify and address these disparities. Funding: There was no funding source for this study. Keywords: Maternal health disparities, ethnicity, race, socioeconomic deprivation, postpartum haemorrhage
16 Jan 2025Submitted to BJOG: An International Journal of Obstetrics and Gynaecology
18 Jan 2025Submission Checks Completed
18 Jan 2025Assigned to Editor
18 Jan 2025Review(s) Completed, Editorial Evaluation Pending
26 Jan 2025Reviewer(s) Assigned