Emanuele De Angelis

and 10 more

Background Endometrial cancer is the most common gynecological malignancy in developed countries. Robotic surgery has been widely adopted across various surgical fields, including gynecologic oncology, yet its benefits compared to traditional approaches, such as laparoscopy and laparotomy, remain uncertain. Objective The present study aimed to evaluate surgical and perioperative outcomes of robotic surgery compared to laparoscopy and laparotomy in the treatment of endometrial cancer. Search Strategy A comprehensive search of the literature was performed up to September 2022, across multiple databases including Pubmed, Embase, Cochrane, to retrieve eligible randomized studies. Selection Criteria Literature was searched for publications reporting robotic surgery for endometrial cancer compared to laparoscopy or laparotomy. Only randomized trial were selected. The risk of bias was evaluated using the Risk of Bias in Randomized Trials tool. Data Collection and Analysis A total of 14 relevant articles were retrieved. After applying inclusion criteria, 8 studies were included in the analysis, encompassing 647 patients: 322 underwent robotic surgery, 244 laparoscopic surgery, and 81 laparotomy. Main Results Robotic surgery was associated with a significant reduction in conversion rates to laparotomy compared to laparoscopy (odds ratio [OR] = 0.17, p = 0.03). No significant differences were observed in other perioperative outcomes. Conclusion Robotic surgery significantly reduces conversion rates to laparotomy in endometrial cancer treatment compared to laparoscopy.