Article type: Case reportTitle: Localised amyloidosis of the oral cavity: a rare clinical entityAuthors: Brian Maloney1, Veronica Fisher2, Claire M. Healy2Affiliations: 1 National Maxillofacial Unit, St. James’s Hospital, James’s Street, Dublin 8, Ireland2 Division of Oral and Maxillofacial Surgery, Medicine, Pathology and Radiology, Dublin Dental University Hospital, Trinity College.ORCID ID: Dr Brian Maloney (0009-0006-2735-9277), Dr Veronica Fisher (0000-0002-2462-4059), Professor Claire M. Healy (0000-0001-6903-2455)Funding: The authors declare that no funding was received for this publicationEthical statement: The study did not require ethical approvalConflict of interest: The authors declare that there are no conflicts of interest in connection with this articleConsent: Written informed consent was obtained from both patients to publish this report in accordance with the journal’s patient consent policy.Corresponding author : Brian Maloney – maloneb3@tcd.ieKeywords: amyloid, fibrils, congo red, immunofixation, electrophoresisFigures : FiveKCM: Amyloidosis is a complex disease which rarely affects the oral cavity. While localised and systemic variants have a similar clinical presentation, These entities differ vastly in their natural history and prognosis. There is a need for practitioners to be aware of the diverse presentation of this disease and the need for further workup.