Introduction:According to the World Health Organization’s international database of adverse reactions, the most frequently reported medicines implicated in drug-induced pancreatitis (DIP) are anti-HIV agents, atypical antipsychotics, azathioprine, mesalazine, estrogens, statins and tetracyclines (1), however, ceftriaxone, a third-generation cephalosporin has also been implicated in causing acute pancreatitis. (2). We report a case of a 62-year-old man with ceftriaxone-induced acute pancreatitis.