Malignant adenomyoepithelioma (MAME) of breast is an uncommon neoplasm, comprising merely 1% of primary breast malignancies. This case report presents a 66-year-old Chinese female presented to the clinic in August 2024 with an observed right breast mass that had been noticed 8 months prior, then the patient underwent a modified radical mastectomy and axillary lymph node dissection, with histopathology demonstrating malignant adenomyoepithelioma. This investigation aims to scrutinize the clinicopathological characteristics of a singular case of MAME while reviewing pertinent literature to augment comprehension regarding this condition.