Chiral framework materials, such as chiral metal-organic frameworks (MOFs) and chiral covalent organic frameworks (COFs), have been extensively reported and studied. However, research on chiral hydrogen-bonded organic frameworks (HOFs) is far behind. HOFs present a novel approach for creating chiral materials, thanks to their mild synthesis conditions, solution processability, and ease of repair and regeneration. This review provides a comprehensive overview of the design and synthesis strategies for chiral HOFs, highlighting recent advancements and exploring the applications of emerging chiral HOFs materials.