Purpose: This study aims to examine the effect of patient-centered communication on the quality of life of cancer patients through a meta-analysis of Randomized Controlled Trials. Methods: Between January 2015 and March 2024, relevant studies were accessed on seven important databases such as Science Direct, Pubmed, Scopus, Web Of Science, Ovid Medline (R), Cochrane Library and Google Scholar. Results: Initially, 1433 studies, including duplicates, were identified through database searches. Once these were imported into Zotero, 538 duplicate studies were removed. After careful evaluation of titles and abstracts against the inclusion and exclusion criteria, only 12 studies met the requirements. These 12 studies were subjected to a detailed review and 4 studies were identified that reported the required statistics and were directly relevant to the topic. Conclusion: Because it is thought that patient-centered communication has a certain limited effect in the advanced stages of cancer patients or when the disease is first learned. This limited effect can be attributed to the fact that patients struggling with the physical, psychological and social effects of cancer keep their communication channels closed, consciously or unconsciously. Moreover, the communication received by patients struggling with the symptoms of the disease may not have an immediate effect. Therefore, it seems necessary to conduct studies with different samples to understand the effects of more patient-centered communication on quality of life.