Introduction
Scleredema is a rare connective tissue disease of unknown pathogenesis,
and may be associated with autoimmune phenomena or allergic responses
[1]. It is characterized by the progressive development of skin
thickening and tightness on the neck and upper part of the body [2].
The prognosis varies according to the etiology and therapeutic options.
In addition to skin lesions, scleredema involves endocrine/metabolic
disorders, cardiovascular disorders, hematologic disorders,
gastrointestinal disorders, and other systemic dysfunctions [3]. In
particular, previous cases reported that scleredema associated
cardiomyopathy, and its pathogenesis may be driven by the lymphocyte
response [4,5]. It is still under investigation in clinical practice
whether scleredema patients develop cardiomyopathy. We report a case of
scleredema in a 32‑year‑old male with cardiomyopathy. The purpose of
this case report is to raise awareness of scleredema-associated
cardiomyopathy and contribute further insight to explore and establish
the foundation for the cause of this uncommon cardiomyopathy.