Fig. 9 TP53BP2 promotes placental autophagy and preeclampsia via G9a, and DNMT1 cooperatively modulates E2F1. The inhibition of TP53BP2 expression attenuated the progression of PE by inhibiting the autophagy of trophoblasts in SD rats, which was attributed to the fact that G9a-mediated H3K9me2- and DNMT1-mediated DNA hypomethylation suppressed the binding of E2F1 at the TP53BP2 promoter to suppress the expression of TP53BP2 transcription and subsequently inhibited the release of Beclin-1 from the Bcl-2-Beclin-1 complex.