References
1. Emeruwa, U.N., Gyamfi-Bannerman, C. and Laurent, L.C. (2023) Biomarkers and the Risk of Preeclampsia. Jama , 329 , 539-541.2. Soobryan, N., Reddy, K., Ibrahim, U.H., Moodley, J., Kumar, A. and Mackraj, I. (2024) Identification of gene signature markers in gestational hypertension and early-onset preeclampsia. Placenta ,145 , 1-8.3. Huang, C., Wei, K., Lee, P.M.Y., Qin, G., Yu, Y. and Li, J. (2022) Maternal hypertensive disorder of pregnancy and mortality in offspring from birth to young adulthood: national population based cohort study. BMJ , 379 , e072157.4. Sacks, D.A. and Incerpi, M.H. (2024) Of Aspirin, Preeclampsia, and Racism. N Engl J Med , 390 , 968-969.5. Vargas, J.N.S., Hamasaki, M., Kawabata, T., Youle, R.J. and Yoshimori, T. (2023) The mechanisms and roles of selective autophagy in mammals. Nat Rev Mol Cell Biol , 24 , 167-185.6. Li, C., Liu, W., Lao, Q., Lu, H. and Zhao, Y. (2022) Placenta autophagy is closely associated with preeclampsia. Aging , 14 .7. Ling, Q., Zhang, Y.-F., Chang, W., Liu, S.-T., Zhu, H.-L. and Wang, H. (2024) NBR1-dependent autophagy activation protects against environmental cadmium-evoked placental trophoblast senescence. Chemosphere , 358 , 142138.8. Chen, Y., Xiao, L., Xu, J., Wang, J., Yu, Z., Zhao, K., Zhang, H., Cheng, S., Sharma, S., Liao, A. et al. (2023) Recent insight into autophagy and immunity at the maternal-fetal interface. J Reprod Immunol , 155 , 103781.9. Ma, F., Ding, N., Xie, L., Zhao, X., Ma, S., Li, G., Hao, Y., Xiong, J., Wu, K., Jiang, Y. et al. (2024) Inhibition of autophagy via 3-methyladenine alleviates the progression of preeclampsia. Acta Biochim Biophys Sin (Shanghai) .10. Guan, G., Zhang, T., Ning, J., Tao, C., Gao, N., Zeng, Z., Guo, H., Chen, C.-C., Yang, J., Zhang, J. et al. (2024) Higher TP53BP2 expression is associated with HBsAg loss in peginterferon-α-treated patients with chronic hepatitis B. J Hepatol , 80 , 41-52.11. Micheal, S., Saksens, N.T.M., Hogewind, B.F., Khan, M.I., Hoyng, C.B. and den Hollander, A.I. (2018) Identification of TP53BP2 as a Novel Candidate Gene for Primary Open Angle Glaucoma by Whole Exome Sequencing in a Large Multiplex Family.Mol Neurobiol , 55 , 1387-1395.12. Huo, Y., Cao, K., Kou, B., Chai, M., Dou, S., Chen, D., Shi, Y. and Liu, X. (2023) TP53BP2: Roles in suppressing tumorigenesis and therapeutic opportunities.Genes Dis , 10 , 1982-1993.13. Braithwaite, A.W., Del Sal, G. and Lu, X. (2006) Some p53-binding proteins that can function as arbiters of life and death. Cell death and differentiation ,13 , 984-993.14. Wu, T., Song, H., Xie, D., Zhao, B., Xu, H., Wu, C., Hua, K., Deng, Y., Ji, C., Hu, J. et al. (2018) Silencing of ASPP2 promotes the proliferation, migration and invasion of triple-negative breast cancer cells via the PI3K/AKT pathway. Int J Oncol , 52 , 2001-2010.15. Wang, Y., Wang, X.D., Lapi, E., Sullivan, A., Jia, W., He, Y.W., Ratnayaka, I., Zhong, S., Goldin, R.D., Goemans, C.G. et al. (2012) Autophagic activity dictates the cellular response to oncogenic RAS. Proc Natl Acad Sci U S A ,109 , 13325-13330.16. Liu, Z., Qiao, L., Zhang, Y., Zang, Y., Shi, Y., Liu, K., Zhang, X., Lu, X., Yuan, L., Su, B. et al. (2017) ASPP2 Plays a Dual Role in gp120-Induced Autophagy and Apoptosis of Neuroblastoma Cells. Front Neurosci , 11 , 150.17. Yao, J., Yang, H., Wang, H., Shi, H., Jiao, Y., Zhang, Y., Chen, D. and Shi, H. (2022) ASPP2 Coordinates ERS-Mediated Autophagy and Apoptosis Through mTORC1 Pathway in Hepatocyte Injury Induced by TNF-α. Front Pharmacol , 13 , 865389.18. Sa, R., Ma, J., Yang, J., Li, D.F., Du, J., Jia, J.C., Li, Z.Y., Huang, N., A, L., Sha, R. et al. (2023) High TXNIP expression accelerates the migration and invasion of the GDM placenta trophoblast. BMC Pregnancy Childbirth ,23 , 235.19. Li, S., Li, L., Zhang, C., Fu, H., Yu, S., Zhou, M., Guo, J., Fang, Z., Li, A., Zhao, M. et al. (2023) PM2.5 leads to adverse pregnancy outcomes by inducing trophoblast oxidative stress and mitochondrial apoptosis via KLF9/CYP1A1 transcriptional axis.Elife , 12 .20. Knihtilä, H.M., Kachroo, P., Shadid, I., Raissadati, A., Peng, C., McElrath, T.F., Litonjua, A.A., Demeo, D.L., Loscalzo, J., Weiss, S.T. et al. (2023) Cord blood DNA methylation signatures associated with preeclampsia are enriched for cardiovascular pathways: insights from the VDAART trial.EBioMedicine , 98 , 104890.21. Garau, J., Charras, A., Varesio, C., Orcesi, S., Dragoni, F., Galli, J., Fazzi, E., Gagliardi, S., Pansarasa, O., Cereda, C. et al. (2023) Altered DNA methylation and gene expression predict disease severity in patients with Aicardi-Goutières syndrome. Clinical immunology (Orlando, Fla.) , 249 , 109299.22. Preissl, S., Gaulton, K.J. and Ren, B. (2023) Characterizing cis-regulatory elements using single-cell epigenomics. Nat Rev Genet , 24 , 21-43.23. Nabais, M.F., Gadd, D.A., Hannon, E., Mill, J., McRae, A.F. and Wray, N.R. (2023) An overview of DNA methylation-derived trait score methods and applications. Genome biology , 24 , 28.24. Kim, J., Lee, H., Yi, S.-J. and Kim, K. (2022) Gene regulation by histone-modifying enzymes under hypoxic conditions: a focus on histone methylation and acetylation. Exp Mol Med , 54 , 878-889.25. Papanicolau-Sengos, A. and Aldape, K. (2022) DNA Methylation Profiling: An Emerging Paradigm for Cancer Diagnosis. Annual review of pathology , 17 , 295-321.26. Barcena-Varela, M., Paish, H., Alvarez, L., Uriarte, I., Latasa, M.U., Santamaria, E., Recalde, M., Garate, M., Claveria, A., Colyn, L. et al. (2021) Epigenetic mechanisms and metabolic reprogramming in fibrogenesis: dual targeting of G9a and DNMT1 for the inhibition of liver fibrosis. Gut ,70 , 388-400.27. Sun, S., Aguirre-Gamboa, R. and Barreiro, L.B. (2023) Transmission of stimulus-induced epigenetic changes through cell division is coupled to continuous transcription factor activity.Frontiers in immunology , 14 , 1129577.28. Kassab, A., Gupta, I. and Moustafa, A.-E.A. (2023) Role of E2F transcription factor in oral cancer: Recent insight and advancements. Seminars in cancer biology , 92 , 28-41.29. Manickavinayaham, S., Velez-Cruz, R., Biswas, A.K., Chen, J., Guo, R. and Johnson, D.G. (2020) The E2F1 transcription factor and RB tumor suppressor moonlight as DNA repair factors. Cell Cycle , 19 , 2260-2269.30. Al-Kharashi, L.A., Bakheet, T., AlHarbi, W.A., Al-Moghrabi, N. and Aboussekhra, A. (2021) Eugenol modulates genomic methylation and inactivates breast cancer-associated fibroblasts through E2F1-dependent downregulation of DNMT1/DNMT3A. Molecular carcinogenesis ,60 , 784-795.31. Ashok, C., Ahuja, N., Natua, S., Mishra, J., Samaiya, A. and Shukla, S. (2021) E2F1 and epigenetic modifiers orchestrate breast cancer progression by regulating oxygen-dependent ESRP1 expression. Oncogenesis , 10 , 58.32. Xie, L., Ding, N., Sheng, S., Zhang, H., Yin, H., Gao, L., Zhang, H., Ma, S., Yang, A., Li, G. et al. (2023) Cooperation between NSPc1 and DNA methylation represses HOXA11 expression and promotes apoptosis of trophoblast cells during preeclampsia. Acta Biochim Biophys Sin (Shanghai) .33. Guo, W., Zhang, H., Yang, A., Ma, P., Sun, L., Deng, M., Mao, C., Xiong, J., Sun, J., Wang, N. et al. (2020) Homocysteine accelerates atherosclerosis by inhibiting scavenger receptor class B member1 via DNMT3b/SP1 pathway. J Mol Cell Cardiol , 138 , 34-48.34. Millán-Zambrano, G., Burton, A., Bannister, A.J. and Schneider, R. (2022) Histone posttranslational modifications - cause and consequence of genome function. Nat Rev Genet , 23 , 563-580.35. Ma’ayeh, M. and Costantine, M.M. (2020) Prevention of preeclampsia. Seminars in fetal & neonatal medicine ,25 , 101123.36. Rana, S., Lemoine, E., Granger, J.P. and Karumanchi, S.A. (2019) Preeclampsia: Pathophysiology, Challenges, and Perspectives. Circulation research , 124 , 1094-1112.37. Nakashima, A., Cheng, S.-B., Ikawa, M., Yoshimori, T., Huber, W.J., Menon, R., Huang, Z., Fierce, J., Padbury, J.F., Sadovsky, Y. et al. (2020) Evidence for lysosomal biogenesis proteome defect and impaired autophagy in preeclampsia. Autophagy , 16 , 1771-1785.38. Ji, J., Zhou, X., Xu, P., Li, Y., Shi, H., Chen, D., Li, R. and Shi, H. (2019) Deficiency of apoptosis-stimulating protein two of p53 ameliorates acute kidney injury induced by ischemia‒reperfusion in mice through upregulation of autophagy. J Cell Mol Med ,23 , 2457-2467.39. Wang, S., Sun, Y., Wang, Y., Wang, A., Kou, B., Che, Y., Chen, D., Zhang, Y. and Shi, Y. (2021) ASPP2 inhibits hepatitis B virus replication by preventing nucleus translocation of HSF1 and attenuating the transactivation of ATG7. J Cell Mol Med ,25 , 6899-6908.40. Hogg, S.J., Beavis, P.A., Dawson, M.A. and Johnstone, R.W. (2020) Targeting the epigenetic regulation of antitumour immunity. Nat Rev Drug Discov , 19 , 776-800.41. Zuccarello, D., Sorrentino, U., Brasson, V., Marin, L., Piccolo, C., Capalbo, A., Andrisani, A. and Cassina, M. (2022) Epigenetics of pregnancy: looking beyond the DNA code. Journal of assisted reproduction and genetics , 39 , 801-816.42. Chen, Z. and Zhang, Y. (2020) Role of Mammalian DNA Methyltransferases in Development.Annu Rev Biochem , 89 , 135-158.43. Kan, R.L., Chen, J. and Sallam, T. (2022) Crosstalk between epitranscriptomic and epigenetic mechanisms in gene regulation. Trends Genet , 38 , 182-193.44. Bai, L., Hao, X., Keith, J. and Feng, Y. (2022) DNA Methylation in Regulatory T-Cell Differentiation and Function: Challenges and Opportunities. Biomolecules , 12 .45. Navarro-Lafuente, F., Adoamnei, E., Arense-Gonzalo, J.J., Prieto-Sánchez, M.T., Sánchez-Ferrer, M.L., Parrado, A., Fernández, M.F., Suarez, B., López-Acosta, A., Sánchez-Guillamón, A. et al. (2022) Maternal urinary concentrations of bisphenol A during pregnancy are associated with global DNA methylation in cord blood of newborns in the ”NELA” birth cohort. The Science of the total environment ,838 , 156540.46. Kassab, A., Gupta, I. and Moustafa, A.A. (2023) Role of E2F transcription factor in oral cancer: Recent insight and advancements. Seminars in cancer biology , 92 , 28-41.47. Gao, C., Dong, R., Li, Y., Liang, J. and Tian, H. (2021) MCTS1 promotes the development of lung adenocarcinoma by regulating E2F1 expression.Oncology letters , 22 , 531.48. Deng, X., Hua, K., Munankarmy, A., Luo, Q., Wang, X. and Fang, L. (2023) E2F1-mediated ectopic expression of PP1A promotes breast cancer progression via activation of YAP1. The international journal of biochemistry & cell biology , 157 , 106389.49. Almacellas, E., Pelletier, J., Manzano, A., Gentilella, A., Ambrosio, S., Mauvezin, C. and Tauler, A. (2019) Phosphofructokinases Axis Controls Glucose-Dependent mTORC1 Activation Driven by E2F1. iScience , 20 , 434-448.50. Haim, Y., Blüher, M., Slutsky, N., Goldstein, N., Klöting, N., Harman-Boehm, I., Kirshtein, B., Ginsberg, D., Gericke, M., Guiu Jurado, E. et al. (2015) Elevated autophagy gene expression in adipose tissue of obese humans: A potential non-cell-cycle-dependent function of E2F1. Autophagy , 11 , 2074-2088.51. Li, Y., Chen, X. and Lu, C. (2021) The interplay between DNA and histone methylation: molecular mechanisms and disease implications. EMBO Rep ,22 , e51803.52. Hashimoto, H., Vertino, P.M. and Cheng, X. (2010) Molecular coupling of DNA methylation and histone methylation.Epigenomics , 2 , 657-669.53. Sun, X., Jin, K., Ding, X., Ruan, Z. and Xu, P. (2023) DNA methylation cooperates with H3K9me2 at HCN4 promoter to regulate the differentiation of bone marrow mesenchymal stem cells into pacemaker-like cells. PLoS One , 18 , e0289510.54. Xiong, J., Ma, F., Ding, N., Xu, L., Ma, S., Yang, A., Hao, Y., Zhang, H. and Jiang, Y. (2021) miR-195-3p alleviates homocysteine-mediated atherosclerosis by targeting IL-31 through its epigenetics modifications. Aging Cell , 20 , e13485.