Background & Objective Blood loss during and after caesarean section is a key determinant of maternal mortality, especially in low- and middle-income countries. This systematic review aimed to identify effective non-pharmacological interventions for reducing blood loss during and after caesarean section. Search Strategy Multiple databases were searched from inception to December 2023. Selection Criteria Prospective studies of women undergoing caesarean section assessing non-pharmacological interventions reporting estimated blood loss and/or post-partum haemorrhage were included. Retrospective studies and study populations not representative of the general caesarean section cohort were excluded. A difference in blood loss of >250ml or a relative risk reduction in post-partum haemorrhage of >25% was considered clinically important. Data Collection and Analysis Data was double extracted. Network meta-analyses and conventional pairwise meta-analyses were performed where appropriate. Risk of bias was assessed using Cochrane RoB 2 or ROBINS-I tools. Main Results 97 studies were eligible for inclusion. 40 were synthesised in five distinct network meta-analyses (caesarean section surgical technique, placenta removal technique, timing of umbilical cord clamping, peritoneum closure and patient warming) and 36 in six pairwise meta-analyses (staple uterine incision, sharp versus blunt expansion of uterine incision, cervical dilatation, extra versus intra-abdominal uterine repair, suture material, and one versus two-layer uterine closure). None of the intervention groups were associated with a clinically important effect. Conclusions The published trials of non-pharmacological interventions on blood loss associated with caesarean section are inconclusive. There is a need for collaborative trials to identify effective and generalisable interventions. A key focus should be interventions that may be impactful in low resource settings where blood loss is the dominant determinant of maternal mortality related to caesarean section.