Detachment of aortic valve calcification lesions leading to arterial embolism is very rare in clinical practice, and is occasionally caused by surgical operation and external interference. Due to the different embolization sites, the clinical symptoms and imaging manifestations are also different, and insufficient knowledge of clinicians can easily lead to missed diagnosis and diagnostic errors. We report a very rare emergency case of a 36-year-old patient presenting with sudden syncope for 4 hours. Echocardiography revealed severe calcification of the aortic valve and active foci. Strong echoic lesions were also found in the distal segment of the brachiocephalic trunk, causing severe stenosis. We consider that the calcification loss of the aortic valve leads to insufficient blood supply to the brain and the occurrence of syncope. The patient received timely surgical treatment. Although the active detachment of aortic valve calcification lesions is very rare, we still need to consider this possibility.