Flexible piezo-driven pressure sensors are crucial for advancing healthcare, especially in muscle activity monitoring and detection. We present graphene oxide (GO) composite hydrogel-based sensors offering high sensitivity, flexibility, and biocompatibility. The piezoelectric GO hydrogel sensor delivers a sensitivity of 0.293 kPa⁻¹ within a 12.5 kPa range, a detection limit of 12.5–150 kPa, and a peak output of 1.0 V under forces of 10–60 N, enabling precise, non-invasive biomechanical monitoring for diagnostics and rehabilitation. Complementing this, the piezoresistive GO hydrogel sensor provides a sensitivity of 0.038 kPa⁻¹ at a 7.5 kPa range, a detection limit of 2.5–35 kPa, and a maximum resistance of 0.9 MΩ under forces of 2–14 N, making it ideal for applications requiring broad pressure detection and consistent performance across variable forces.