The increasing sophistication of cyberattacks has necessitated the development of innovative detection mechanisms capable of identifying malicious activities with high accuracy and minimal latency. Through the integration of Structural Mutation Analysis and quantum-inspired techniques, a robust framework was proposed to address the challenges posed by modern ransomware variants. The approach leveraged advanced pattern recognition methodologies to capture the structural and behavioral anomalies introduced during ransomware execution, enabling precise classification. Quantum-inspired principles facilitated the identification of complex, non-linear relationships within file trace sequences, enhancing the system's ability to detect previously unseen threats. By employing a combination of reinforcement learning and hybrid machine learning architectures, the detection system demonstrated adaptability and scalability across diverse datasets and attack scenarios. The experimental results highlighted the system's efficiency in handling polymorphic and hybrid encryption schemes, maintaining accuracy rates exceeding 94% and low false-positive rates. A modular system architecture ensured seamless integration with existing cybersecurity infrastructures while supporting real-time operations through efficient computational pipelines. Additionally, empirical analyses revealed that the method provided actionable insights into ransomware propagation dynamics, enabling early-stage mitigation strategies. Advanced visualization techniques further contributed to the interpretability of the detection outcomes, reinforcing its practical applicability.