Studies have shown that surgical site infections have increased due to the decrease in the use of cefazolin for perioperative prophylaxis and the prescription of alternative antibiotics to β-lactams. Patients with reported penicillin allergy are often treated with alternative antibiotics that are broader in spectrum, more toxic, and more expensive. One study found a 69% increase in the risk of methicillin-resistant Staphylococcus aureus (MRSA) and a 26% increase in the risk of C. difficile infection due to this condition.11,12 Therefore, it is of increasing importance to perform confirmation tests in patients who report a history of allergy. This is supported by the study showing that out of 460 patients reporting penicillin allergy, only 17 patients (3.7%) had a positive allergy test.13 In another study in which a confirmation test was performed, it was found that the use of cefazolin increased by 18%, while the use of vancomycin and clindamycin decreased significantly.14 In our study, no patient underwent a confirmation test or allergy test as there was no specific protocol in our hospital. Only patients who reported multiple drug allergies were registered for follow-up at the allergy and immunology clinic after discharge.