As in our study, individual drug allergens are reported to be significantly more prevalent in female patients in many studies. In addition, a history of drug allergy has been reported more frequently in elderly patients due to the burden caused by polypharmacy.6,7 In a similar study conducted with a similar number of patients to our study population, the rate of penicillin allergy was found to be 4.6% in 5529 hospitalized patients. This rate was found to be 2.1% in our study. However, we did not perform allergy or confirmation tests on any of the patients. In the literature, confirmation testing and proposing studies have become increasingly important in recent years. Steenvoorden et al. reported that penicillin treatment was administered safely in 42% of patients who reported penicillin allergy after oral penicillin testing.8 In patients with a penicillin allergy label, the actual penicillin hypersensitivity rate is less than 5%. The possibility of cross-reaction between penicillins and cephalosporins is extremely low (1-2%). However, if penicillin allergy is present, most surgeons avoid cefazolin in surgical prophylaxis for fear of cross-reaction. This should be considered as a surgical tradition that has no scientific basis since studies have shown that cefazolin is safer than other cephalosporins due to a different heterocyclic ring in its pharmacological structure.9 In the general surgery clinic where our study was performed, ciprofloxacins are preferred for surgical prophylaxis in patients with penicillin or cephalosporin allergy labels. This is mainly because ciprofloxacin is considered safer. However, Hartinger et al. reported that neurotoxicities and other serious adverse effects related to ciprofloxacin were observed in their study.10