Comparison of efficacy between the group receiving ICI and the
group not receiving ICI
After inclusion and exclusion criteria, 127 patients were enrolled in
the study, including 65 patients who received immunotherapy and 62
patients who did not receive immunotherapy. Patients in both groups were
evaluated retrospectively by imaging with enhanced CT at 2-month
intervals. Refer to Response Evaluation Criteria in Solid Tumors version
1.1(RECIST version 1.1)20, Complete Response (CR):
Disappearance of all target lesions, any pathological lymph nodes
(whether target or non-target) must have reduction in short axis to
sum of diameters of target lesions, taking as reference the baseline sum
diameters; Progressive Disease (PD): At least a 20% increase in the sum
of diameters of target lesions, taking as reference the smallest sum on
study (this includes the baseline sum if that is the smallest on study).
In addition to the relative increase of 20%, the sum must also
demonstrate an absolute increase of at least 5 mm. (Note: the appearance
of one or more new lesions is also considered progression); Stable
Disease (SD): Neither sufficient shrinkage to qualify for PR nor
sufficient increase to qualify for PD, taking as reference the smallest
sum diameters while on study. The results showed that of the 65 patients
in the group receiving immunotherapy, 21 patients with PD, 40 patients
with SD, 4 patients with PR, 4 patients met the criteria for objective
response, and 44 patients met the criteria for disease control; and of
the 62 patients in the group not receiving immunotherapy, 17 patients
with PD, 43 patients with SD, 2 patients with PR, 2 patients met the
criteria for objective response, and 45 patients met the criteria for
disease control. The results of the different evaluations of the two
groups of patients were statistically analysed separately, and the
results using the Chi-square test and Fisher’s exact test were as
follows: in the case of PD or not, there was no statistical difference
between the two groups, P =0.548; in the case of SD or not, there
was no statistical difference between the two groups, P =0.355; in
the case of PR or not, there was no statistical difference between the
two groups, P =0.680; in the case of objective response or not,
there is no statistical difference between the two groups,P =0.680; in the case of disease control or not, there is no
statistical difference between the two groups, P =0.548, as shown
in Table 2.
Table 2 Comparison of efficacy between the group with ICI and
the group without ICI