There should be at least 3 relatives with any Lynch Syndrome-associated
cancer (colorectal cancer, cancer of the endometrium, small bowel,
ureter, or renal pelvis) |
1 should be a first-degree relative of the other two |
At least 2 successive generations should be affected |
At least 1 should be diagnosed before age 50 |
Familial adenomatous polyposis should be excluded in the colorectal
cancer case(s), if any |
Tumors should be verified by pathological examinations |