Amsterdam II criteria for Lynch Syndrome
There should be at least 3 relatives with any Lynch Syndrome-associated cancer (colorectal cancer, cancer of the endometrium, small bowel, ureter, or renal pelvis)
1 should be a first-degree relative of the other two
At least 2 successive generations should be affected
At least 1 should be diagnosed before age 50
Familial adenomatous polyposis should be excluded in the colorectal cancer case(s), if any
Tumors should be verified by pathological examinations