Based on new zircon and apatite (U-Th-Sm)/He and 40Ar/39Ar ages, along with published thermochronometric data, we derive first-order constraints on the tectonic and thermal evolution of the Dent Blanche Tectonic System (DBTS), an Austroalpine nappe in the Western Alps underlain by former Ligure-Piemontese oceanic units. Overall, ZHe ages are approximately 30 Ma, and most AHe ages are younger, ranging from ~20 to ~12 Ma, with exceptionally young ages (~2.5 Ma) from a sample collected at a lower elevation in the Valpelline Valley. MAr ages are scattered, spanning from ~250 Ma to ~29 Ma, and many micas are affected by excess radiogenic 40Ar *. Inverse thermal modeling of the cooling ages, constrained with the younger MAr ages from the same samples, indicates that DBTS experienced rapid cooling associated with the Alpine orogeny during the Eocene-Oligocene. Since then, cooling has slowed one to two-fold compared to adjacent units to the north. The Pliocene-Pleistocene AHe ages from the Valpelline Valley were reset and experienced rapid cooling starting around ~2.5 Ma. This increase in cooling is interpreted as the localized effect of glacial erosion, which steepened tributary valleys adjoining the Aosta Valley, as indicated by the analysis of normalized fluvial channel steepness (Ksn). This is consistent with similar increased denudation rates since the Pliocene, as reported in the Rhone Valley and Mont Blanche area of the Western Alps.