Gastrointestinal lesions complicated by systemic lupus erythematosus occur from time to time in clinical practice, but it is not common to have gastrointestinal lesions as the main clinical manifestation and negative typical antibodies. There is currently no unified diagnostic standard, which is easy to miss or misdiagnose. Recently, our department admitted a patient with this condition. This article summarizes the diagnosis and treatment experience in combination with relevant literature analysis.