Air pollution is estimated to result in approximately 6.7 million premature mortalities annually, more than 74000 of which may be attributable to aviation emissions. Recent studies of aviation’s environmental impacts have solely focused on the climate impacts of aviation NOx, suggesting they are small and uncertain relative to those of aviation CO2. These analyses have neglected the air quality (AQ) impacts of NOx, which previous studies have found to be substantial, and for which the monetized damages may be of a similar order of magnitude to aviation’s net climate impacts. The AQ impacts are due to surface population exposure to ozone and PM2.5 due to local and transported emissions. To analyze this, prior studies have evaluated global average values of the sensitivity of changes in these parameters to emissions. However, a limitation of this approach is that it does not allow for a spatial differentiation of the impacts at high resolutions.This work addresses this limitation by using a finite difference approach to determine the sensitivity of AQ impacts in regions of interest to aviation emissions at different regions. Simulations with a 0.5° x 0.5° resolution of the region of interest will enable analyzing the effect of the prevailing background conditions of that region on AQ, for which effects on climate have been explored. The GEOSChem High Performance global chemistry transport model with stretched-grid simulation capability will be used, which can model regions of interest at high resolution efficiently without significant increases in computational time. For our analysis, flights in South Asia and East Asia & Pacific, which are aviation hotspots, are chosen for aircraft and engines which have the largest share of impact. This analysis will help shape aviation policies to minimize the environmental damages of aviation by understanding the impact of technology improvements on different types of aircraft. Furthermore, this high-resolution regional data will provide a foundation for analyzing the distributional inequities in aviation AQ impacts. Future work following this study will involve evaluating the total monetized impacts of aviation for damages due to both AQ and climate for different regions.