Introduction: Cancer and atrial fibrillation (AF) are major public health challenges in the United States, with significant mortality risks and a bidirectional relationship that compounds their burden. Despite substantial documentation of their independent mortality trends, data on concomitant cancer- and AF-related mortality trends remain limited. Methods and Results: We analyzed cancer- and AF-related mortality in the U.S. from 1999 to 2019 using CDC WONDER data, focusing on adults aged ≥25 years. Crude and age-adjusted mortality rates (AAMRs) were calculated, and trends were evaluated using Joinpoint regression. A total of 319,480 deaths were identified, with the AAMR increasing from 4.95 in 1999 to 10.01 in 2019 (AAPC: 3.49%). Males exhibited higher AAMRs than females, while Hispanics demonstrated the greatest increase. Geographic disparities were evident, with the highest AAMRs in Vermont, Minnesota, and Rhode Island and the lowest in Arizona, Georgia, and New Mexico. Conclusion: Cancer- and AF-related mortality has risen significantly over two decades, with notable racial, sex-based, and geographic disparities. These findings underscore the need for targeted interventions to address these inequities and mitigate the growing burden of coexisting cancer and AF.

Background: Atrial fibrillation (AF) and dementia are increasingly prevalent in aging U.S. populations. Their association raises public health concerns, emphasizing the need to understand mortality trends in older adults. This study examines AF and dementia-related mortality trends from 2000 to 2020. Methods: Using the CDC WONDER Multiple Cause of Death database, we analyzed death certificates for individuals aged 65 and older, reporting age-adjusted mortality rates (AAMRs) per 100,000 persons. Trends were assessed through annual percent change (APC) analysis via Joinpoint regression, with stratifications by sex, race/ethnicity, urbanization, and Census regions. Results: A total of 400,103 AF and dementia-related deaths were recorded between 2000 and 2020. The AAMR increased markedly from 25.4 in 2000 to 70.4 in 2020. The overall AAMR showed a steady increase from 2000 to 2018 (APC: +4.4%; 95% CI: 3.7–4.8), with a sharper rise from 2018 to 2020 (APC: +9.5%; 95% CI: 4.5–12.2; p < 0.001). Mortality rates were comparable between men (AAMR: 72.7) and women (AAMR: 71.6). NH White individuals exhibited the highest AAMR (47.0), followed by NH Black (26.6), Hispanic (23.1), and NH Asian/Pacific Islander (18.0) populations. Nonmetropolitan areas had higher AAMRs (48.1) compared to metropolitan areas (43.5). Regionally, the Western U.S. recorded the highest AAMR at 48.2, while state-level disparities showed a nearly threefold difference between the top 90th and bottom 10th percentiles. Conclusion: Rising AF and dementia-related mortality rates among older adults highlight a need for targeted screening and intervention, particularly for high-risk demographics and underserved regions.