The COVID-19 pandemic has significantly influenced consumer behaviour, notably increasing online grocery shopping. This shift raises food safety concerns for perishable items like raw chicken, as delivery temperature fluctuations can elevate microbial loads, including Salmonella enterica serovar Typhimurium (S. Typhimurium), a major cause of salmonellosis. This study examines plasmid profiles and antibiotic resistance patterns of S. Typhimurium from raw chicken purchased from three Malaysian online retailers.Seventy-two isolates were collected between January and March 2023 from Brand A (Kedah, 38 isolates), Brand B (Selangor, 19 isolates), and Brand C (Negeri Sembilan, 15 isolates). Testing against 12 antibiotics showed all isolates were resistant to three or more antibiotics, with 63% resistant to six or more. High resistance was observed for vancomycin (100%) and tetracycline (91%). Plasmids carrying resistance traits were transferred from two resistant isolates to E. coli DH5α. These findings suggest raw chicken from online retailers may act as reservoirs of multidrug-resistant plasmids.