Atmospheric Pressure Solids Analysis Probe (ASAP) Mass Spectrometry was used for the rapid analysis of 250 synthetic opioid standards, including 210 fentanyl analogs of similar molecular weight and structure, 32 non-fentanyl related opioids, and 8 fentanyl precursors. Using four cone voltages (5, 15, 35 and 50 V) both precursor and product ion mass information was obtained for all standards. The accumulated spectral data was used to build a spectral library, which was utilized to create and validate a statistical model via LiveID software. To assess the accuracy of the database, 5 blind and 4 dirty cook fentanyl samples were analyzed. Using LiveID, obtained data for each sample was processed and matched against all compounds in the spectral library to produce matching scores that ranged from 0- 999. For all samples, the correct identity of each fentanyl analog was ranked within a score of 800 -997. Thus, proving that ASAP, when used alongside a real-time sample recognition software, such as LiveID, can help conduct presumptive testing for fentanyl and fentanyl analogs in blind and dirty samples, making it a promising alternative to some of the most commonly used analytical screening techniques.