Abstract

not-yet-known not-yet-known not-yet-known unknown Heart failure is the end stage of many cardiovascular diseases, with high morbidity, mortality and re-hospitalization rates, which brings a huge medical burden and economic pressure to the society. Inflammation has a significant impact on the development, progression and prognosis of heart failure. Although a growing number of studies have demonstrated the critical role of NLRP3 inflammasome in HF, a bibliometric analysis of research hotspots and trends in this area has not been performed. In this study, we retrieved articles related to NLRP3 inflammasome in HF from the Web of Science Core Collection (WoSCC) database for the period of 2010 - 2024 and analyzed them using visualization tools such as Citespace, VOSviewer, Scimago Graphica, and Microsoft Office Excel 2021 and other visualization tools to analyze the data. After screening, we included a total of 282 papers published by 2130 researchers from 500 institutions in 35 countries/regions, with relevant papers published in 133 journals. China played an important part in this field, with the highest outputs. Abbate, Antonio was the most published author, The institutions that publish the most papers were Virginia Commonwealth University, Wuhan University, INTERNATIONAL IMMUNOPHARMACOLOGY were the most published journal, CIRCULATION was the most cited journal with the highest number of citations, which has had a greater impact on the research in this field. The current research hotspots focus on the activation and inhibition pathways of NLRP3 inflammasome, the exploration of novel targets of HF, and the connection between HF and mitochondria. The relationship between HF and pyroptosis, the clinical study of drugs related to NLRP3 inflammasome as a therapeutic target of HF are a trend for future research. Our study provides a comprehensive bibliometric analysis and summary of NLRP3 inflammasome -related studies in HF, and the analysis provides a theoretical basis for the study of NLRP3 inflammasome in HF and provides guidance for future research directions.